Buccal space malignant solitary fibrous tumour: a case report
DOI:
https://doi.org/10.18203/2349-2902.isj20220655Keywords:
Solitary fibrous tumour, Malignant SFT, Buccal space lesion, HemangiopericytomaAbstract
Solitary fibrous tumour (SFT) occurs rarely in extrapleural sites such as head and neck region. Head and neck region is affected in 16% cases occurring usually in orbit and paranasal region and are benign variants. Though usually benign, Malignant SFT in buccal space is extremely rare and comes with challenges in diagnosis and management. We report a rare case of Malignant SFT in the buccal space in a 70-year-old- gentleman who presented with slow growing mass in left cheek. Patient was treated with surgical excision and adjuvant radiotherapy and is on regular follow up. Malignant SFTs are difficult to diagnose due to lack of specific histological pattern but certain IHC and genomic markers can help. Buccal space malignant SFT can be managed by wide local excision and adjuvant radiotherapy in cases of large tumour size and margin positive resection.
References
Klemperer P, Rabin CB. Primary neoplasms of the pleura. Arch Pathol (Chic). 1931;11:385e412.
Mastrangelo G, Coindre JM, Ducimetiere F. Incidence of soft tissue sarcoma and beyond: a population-based prospective study in 3 European regions. Cancer. 2012;118:5339-48.
Witkin GB, Rosai J. Solitary fibrous tumor of the upper respiratory tract. A report of six cases. Am J Surg Pathol. 1991;15:842e8.
Westra WH, Gerald WL, Rosai J. Solitary fibrous tumor. Consistent CD34 immunoreactivity and occurrence in the orbit. Am J Surg Pathol. 1994;18:992e8.
Fletcher CDM, Bridge JA, Hogendoorn P, editors. WHO Classification of Tumours of Soft Tissue and Bone. Lyon: IARC. 2013.
Marx RE, Stern D. Oral and maxillofacial pathology: a rationale for diagnosis and treatment. Chicago: Quintessence Publishing Co. Inc. 2002;458-9.
Yang XJ, Zheng JW, Ye WM, Wang YA, Zhu HG, Wang LZ et al. Malignant solitary fibrous tumors of the head and neck: a clinicopathological study of nine consecutive patients. Oral Oncol. 2009;45(8):678-82.
Nunes FB, Sant'Ana MS, Silva AM, Agostini M, Silva Canedo NH, De Andrade BA et al. Solitary fibrous tumour of the oral cavity: an update. J Oral Pathol Med. 2020;49(1):14-20.
De Oliveira D, Albuquerque A, De Araújo Barreto MD. Large solitary fibrous tumor of the oral cavity-report of a case. Pathol Res Pract. 2014;210:1064‐7.
Rekhi B, Shetty O, Tripathi P. Molecular characterization of a series of solitary fibrous tumors, including immunohistochemical expression of STAT6 and NATB2‐STAT6 fusion transcripts, using Reverse Transcriptase (RT)‐Polymerase chain reaction (PCR) technique: An Indian experience. Pathol Res Pract. 2017;213:1404‐11.
Gold JS, Antonescu CR, Hajdu C, Ferrone CR, Hussain M, Lewis JJ et al. Clinicopathologic correlates of solitary fibrous tumors. Cancer. 2002;94(4):1057-68.
Bishop AJ, Zagars GK, Demicco EG, Wang WL, Feig BW, Guadagnolo BA. Soft Tissue Solitary Fibrous Tumor. Am J Clin Oncol. 2018;41(1):81-5.
