DOI: http://dx.doi.org/10.18203/2349-2902.isj20221158

Squamous cell carcinoma arising from suprapubic cystostomy: report of two cases and a narrative review of literature

Ricardo Metke, Andrea Araujo, Julian Chavarriaga, Catalina Villaquiran, Juan Guillermo Cataño, Maddy Mejía, Sergio Cervera Bonilla, Julián Chavarriaga, Laura Castillo

Abstract


Squamous cell carcinoma arising from Marjolin’s ulcer of the suprapubic cystostomy tract is a rare entity that usually occurs in patients with a history of spinal cord injuries and a chronic indwelling catheter. We present 2 cases of this rare entity with the clinical exams needed for diagnosis and treatment according to individual characteristics of each case. Marjolin’s ulcer is a cutaneous malignancy that arises from injured skin. The most frequent type of malignancy identified on histopathologic examination is squamous cell carcinoma (80-90%). It can develop from long-standing scars, chronic wounds, pressure ulcers, osteomyelitis, and burns. Only cases have been reported about Marjolin’s ulcer with squamous cell carcinoma at the cystostomy cite. Treatment regimens have not been standardized; cases have received individualized treatments, usually with excision, radiation, or a combination of both. There is insufficient evidence to aid in the understanding of the etiology. In addition, there is no consensus on its optimal treatment and follow-up schemes.


Keywords


Squamous cell carcinoma, Cystostomy, Urinary bladder neoplasms, Spinal cord injuries

Full Text:

PDF

References


Massaro PA, Moore J, Rahmeh T, Morse MJ. Squamous cell carcinoma of the suprapubic tract: A rare presentation in patients with chronic indwelling urinary catheters. Can Urol Assoc J. 2014;8(7-8):E510-4.

Stroumbakis N, Choudhury MS, Hernandez-Graulau JM. Squamous cell carcinoma arising from suprapubic cystotomy site without bladder involvement. Urology. 1993;41(6):568-70.

Bazaliński D, Przybek-Mita J, Barańska B, Więch P. Marjolin’s ulcer in chronic wounds - review of available literature. Contemp Oncol (Pozn). 2017;21(3):197-202.

Abdi MA, Yan M, Hanna TP. Systematic Review of Modern Case Series of Squamous Cell Cancer Arising in a Chronic Ulcer (Marjolin’s Ulcer) of the Skin. JCO Glob Oncol. 2020;6:809-18.

Kaufman JM, Fam B, Jacobs SC, Gabilondo F, Yalla S, Kane JP, et al. Bladder cancer and squamous metaplasia in spinal cord injury patients. J Urol. 1977;118(6):967-71.

Ito H, Arao M, Ishigaki H, Ohshima N, Horita A, Saito I, et al. A case of squamous cell carcinoma arising from a suprapubic cystostomy tract. BMC Urol. 2011;11:20.

Kalisvaart JF, Katsumi HK, Ronningen LD, Hovey RM. Bladder cancer in spinal cord injury patients. Spinal Cord. 2010;48(3):257-61.

West DA, Cummings JM, Longo WE, Virgo KS, Johnson FE, Parra RO. Role of chronic catheterization in the development of bladder cancer in patients with spinal cord injury. Urology. 1999;53(2):292-7.

Ranjan N, Singh RP, Ahmad A, Kumar A, Singh M. Squamous Cell Carcinoma Arising from Suprapubic Cystostomy Tract Along with Bladder Involvement. J Case Reports. 2015;5(2):327-30.

Subramaniam S, Thevarajah G, Kolitha K, Namantha N. Squamous cell carcinoma of suprapubic cystostomy site in a patient with long-term suprapubic urinary catheter. Case Rep Urol. 2017;2017:1-5.

Chung JM, Oh JH, Kang SH, Choi S. Squamous cell carcinoma of the suprapubic cystostomy tract with bladder involvement. Korean J Urol. 2013;54(9):638-40.

Gupta NP, Singh I, Nabi G, Ansari MS, Mandal S. Marjolin’s ulcer of the suprapubic cystostomy site infiltrating the urinary bladder: A rare occurrence. Urology. 2000;56(2):330.

Khadhouri S, Rye DS, Powari M, Daniels IR, McGrath JS. A case report of squamous cell carcinoma in a suprapubic urinary catheter tract: surgical excision and simultaneous colostomy formation. J Surg Case Rep. 2018;2018(2):30.

Stokes S 3rd, Wheeler JS, Reyes CV. Squamous cell carcinoma arising from a suprapubic cystostomy tract with extension into the bladder. J Urol. 1995;154(3):1132-3.

Manzo-Pérez BO, Gómez-Radillo FE, Valladares-Coto BA, Beas-Luna A, Morales-Fonseca JC, Chávez-Solis E, et al. Carcinoma vesical de células escamosas que emerge de tracto fistuloso vesico-cutáneo. Rev Mex Urol. 2012;72(4):197-200.

Schaafsma RJ, Delaere KP, Theunissen PH. Squamous cell carcinoma of suprapubic cystostomy tract without bladder involvement. Spinal Cord. 1999;37(5):373-4.

Boaz RJ, John NT, Kekre N. Squamous cell carcinoma of suprapubic cystostomy tract in a male with locally advanced primary urethral malignancy. Indian J Urol. 2015;31(1):70-2.

Zhang X, Mi Y, Wang D, Yuan X, Zhang B, Bai T. Highly differentiated squamous cell carcinoma arising from a suprapubic cystostomy tract in a patient with transplanted kidney. Int J Clin Exp Med. 2015;8(11):21770-2.