Published: 2016-12-14

Dynamics of degradation of new samples of membrane coating based on cellulose polymers

Viacheslav Alexandrovich Lipatov, Mikhael Alexandrovich Inarkhov, Dmitriy Mutalifovich Yarmamedov, Anna Jurievna Poddelkova, Samuel Bisilki Governor, Prince Twumasi Ankrah


Background:The use of polymeric coating implants is a promising way of preventing adhesion disease and its related complications in the peritoneum. In this paper, the dynamics of degradation of new samples were studied in an in vitro experiment. A sample was then chosen which is potentially suitable for further research in an in vivo experiment.

Methods: In the research, 7 different samples of polymeric coating were studied viz. No. 81 MN, No 82. MN, No. 83 MN, No. 84 MN, No. 85 MN, No. 86 MN and No. 87 MN - developed by Lintex, LCC (St. Petersburg) together with the department of Operative Surgery and Topographical Anatomy named after A.D. Myasnеkov of Kursk State Medical University. The samples were differentiated by subjecting them to different technological processing of temperature, and chemical agents etc.

Results:In the course of the experiment, it was discovered that the rate of degradation of the polymeric coating implants depended on their processing methods.

Conclusions:Membranes that quickly undergo degradation cannot be used for prophylaxis of complications caused by surgical interventions.


Degradation; Polymer; Implantology; Membrane; Film; Adhesion formations

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Boyko VV, Yevtushenko DA. Method of prophylaxis of adhesion-formation, on the organs of the peritoneum, of an early- operated- on- patients. Scientific innovation. 2013;25:177-81.

Adhesion disease of the Peritoneum. Plechev VV, Kiriyenko AI, Savelyev VC. 80 Lectures in surgery. 1st ed. Moscow, Moskva. 2008:456-68.

Khasanov AG, Sufiyarov IF, Nigmatzyanov SS, Matigullin RM. Method of surgical treatment and prophylaxis of post-operative peritoneal adhesion. Surgery Journal named Pirogov. 2008;3:43-5.

Fertil S. The Practice Committee of the American Society for Reproductive Medicine in collaboration with the Society of Reproductive Surgeons. Pathogenesis, consequences, and control of peritoneal adhesions in gynecologic surgery. 2008;90:144-9.

Ansaloni L, Catena F, Coccolini F, Fini M, Gazzotti F, Giardino R, et al. Peritoneal Adhesions to Prosthetic Materials: An Experimental Comparative Study of Treated and Untreated Polypropylene Meshes Placed in the Abdominal Cavity. Journal of Laparoendoscopic & Advanced Surgical Techniques. 2009;19:369-74.

Costa RG, Lontra MB, Scalco P, Cavazzola LT, Gurski RR. Polylactic acid film versus acellular porcine small intestinal submucosa mesh in peritoneal adhesion formation in rats. Acta Cir Bras. 2009;24:128-35.

Degenhardt P, Pelzer M, Fischer B, Kraft S, Sarioglu N, Mau H, et al. Reduction of Postoperative Adhesions by Perfluorocarbons. An Experimental Study in a Rat Model. Eur J Pediatr Surg. 2009;19:211-5.

Zeng Q, Yu Z, You J, Zhang Q. Efficacy and safety of Seprafilm for preventing postoperative abdominal adhesion: systematic review and meta-analysis. World J Surg. 2007;31:2125-31.

Chapter I. In: V. A. Kargin. Encyclopedia of polymers. 4th ed. Moscow: Soviet Encyclopedia. 2000:77.

Stillman MI. Polymers of Medico- biological applications. M. Academic- book. 2nd ed. Moscow, Moskva. 2006:400.

Lipatov VA, Inarhov MA, Zhukovsky VA, Yarmamedov DM, Tsupreva EA. Dynamics of degradation of polymeric coating implants in the conditions of an experiment in vitro.Youth Innovation Gazette. 2013;1:111-2.

Chen L, Hu A, Chang C. The Degradation Mechanism of Toxic Atractyloside in Herbal Medicines by Decoction. Molecules. 2013;18:2018-28.

Ishimoto T, Koyama M. A Review of Molecular-Level Mechanism of Membrane Degradation in the Polymer Electrolyte Fuel Cell. Membranes. 2012;2:395-414.

Ji M, Wei Z. A Review of Water Management in Polymer Electrolyte Membrane Fuel Cells. Energies. 2009;2:1057-106.

Scipioni R, Gazzoli D, Teocoli F, Palumbo O, Paolone A, Ibris N, Brutti S. Preparation and Characterization of Nanocomposite Polymer Membranes Containing Functionalized SnO2 Additives. Membranes. 2014;4:123-42.