DOI: http://dx.doi.org/10.18203/2349-2902.isj20213631

Rare presentation of ectopic thymoma

Deepalakshmi Tanthry, Aisha Nehla, Chethana R., Devan Poothatta Pannen, Mahesh Santhraya, Rukma Bhandary, Vishwas Pai

Abstract


Thymoma is the most common tumor of the anterior mediastinum with an incidence of 0.15 cases per 100,000. Ninety percent of all thymoma occur in the anterior mediastinum, with the remainder occurring in the neck or other mediastinal areas. Ectopic cervical thymoma (ECT) is an extremely rare tumor that originates from ectopic tissue and is caused by the aberrant migration of the embryonic thymus. ECTs are often confused with thyroid or parathyroid swellings due to their anatomical positioning. Intrathyroid epithelial thymoma is a rare tumour comprising about 0.08% of all primary thyroid malignancies. It is low-grade thyroid carcinoma with squamous cell differentiation whose overall survival rate was found to be 71%. Here we presented a case of 43 year old female, came with swelling in front of the neck since many years. Ultrasound neck and fine needle aspiration cytology (FNAC) was performed. Patient underwent total thyroidectomy and specimen obtained was sent for histopathological examination. It revealed ectopic intrathyroid thymoma.


Keywords


Ectopic, Intrathyroid epithelial thymoma, Total thyroidectomy, Fine needle aspiration cytology

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References


Embryology. Fact sheet: Thymus development, 2021. Available at: https://embryology.med.unsw.edu.au/embryology/index.php/Thymus_Development. Accessed on 14 June 2021.

Cohen JB, Troxell M, Kong CS, McDougall IR. Ectopic intrathyroidal thymoma: a case report and review. Thyroid. 2003;13(3):305-8.

Gordon J, Manley N. Mechanism of thymus organogenesis and morphogenesis. Development. 2011;138(18):3865-78.

Pathologyoutlines.com. fact sheet: Thymic tissue, 2021. Available at: https://www.pathologyoutlines.com/topic/thyroidthymictissue.html. Accessed on 14 June 2021.

Stevens TM, Morlote D, Swensen J, Ellis M, Harada S, Spencer S, et al. (2019). Spindle epithelial tumor with thymus-like differentiation (SETTLE): a next-generation sequencing study. Head Neck Pathol. 2019;13(2):162-8.

Dualim DM, Loo GH, Suhaimi SNA, Latar NH, Muhammad R, Shukor NA. (2019). The ‘CASTLE’ tumour: An extremely rare presentation of a thyroid malignancy: a case report. Ann Med Surg (Lond). 2019;44:57-61.

Park HO, Kim SH, Moon SH, Yang JH, Kang DH, Lee JH. Ectopic Cervical Thymoma: A Case Report and Review. Korean J Thorac Cardiovasc Surg. 2017;50(4):312-5.

Wu TH, Jin JS, Huang TW, Chang H, Lee SC. Ectopic cervical thymoma in a patient with Myasthenia gravis. J Cardiothorac Surg. 2011;6:89.