Incidence of Helicobacter pylori in patients with upper gastrointestinal symptoms: a hospital-based study
DOI:
https://doi.org/10.18203/2349-2902.isj20212717Keywords:
Symptoms, Gastritis, Esophagitis, Rapid urease test, PatientsAbstract
Background: Commonest complaints for which patients seek hospital care are upper gastrointestinal (UGI) symptoms. Prevalence of these symptoms range from 8-54%. Most common cause is Helicobacter pylori. The objective of this study was to investigate incidence of Helicobacter pylori in patients with UGI symptoms.
Methods: Hospital-based study was carried out among 200 cases with esophageal disorders, gastric disorders, duodenal disorders, gastro duodenitis. Predesigned and pretested questionnaire was used to record information. Gastric and duodenal biopsy was taken. Rapid antigen test kit was used to identify for Helicobacter pylori.
Results: Incidence of Helicobacter pylori was 80%. Most common disorders associated with UGI symptoms were gastritis (29%), gastritis with duodenal ulcer (21%) and esophagitis (21%). They were more common in males except esophageal varices. Gastritis and esophagitis were significantly more in 21-40 years (46.55%) (p<0.05). Most common age of UGI symptoms was 21-40 years (34.5%). H. pylori infection was more among males (62.50%). Most common indication for endoscopy was dyspepsia in 48 (24%).
Conclusions: Incidence of H. pylori was 80%. Upper GI diseases are more common in men (65.5%) compared to females (34.5%) with the most affected age group between 21-60 years (68%). H. pylori was the commonest cause of chronic gastroduodenitis in this study.
References
Patremane UM, Periyasamy V. Clinical study of endoscopic findings in patients presenting with upper GI symptoms. J Evol Med Dent Sci. 2017;6(94):68-81.
Jemilohun A, Otegbayo J, Ola S, Oluwasola AO, Akere A. Diagnostic accuracy of rapid urease test for the diagnosis of Helicobacter pylori gastric biopsies in Nigerian with dyspepsia. Afr J Clin Exp Microbiol. 2011;12:62-6.
Thapa R, Lakhey M, Yadav PK, Kandel P, Aryal C, Subba K. Histopathological study of endoscopic biopsies. JNMA J Nepal Med Assoc. 2013;52(190):354-6.
Shrestha S, Paudel P, Pradhan GB, Shrestha L, Bhattachan CL. Prevalence study of H. pylori infection in dyspeptic patients coming to Nepal Medical College Teaching Hospital, Jorpati, Kathmandu. Nepal Med Coll J. 2012;14(3):229-33.
Eisen GM, Dominitz JA, Faigel DO, Goldstein JA, Kalloo AN, Petersen BT, et al. The role of endoscopy in dyspepsia. Gastrointest Endosc. 2001;54(6):815-7.
Elghuel A. The characteristics of adults with upper gastrointestinal bleeding admitted to Tripoli Medical Center: a retrospective case-series analysis. Libyan J Med. 2011;6.
Dhakhwa R, Acharya IL, Shrestha HG, Joshi DM, Lama S, Lakhey M. Histopathologic study of chronic antral gastritis. J Nepal Health Res Counc. 2012;10(1):57-60.
Fock KM, Ang TL. Epidemiology of Helicobacter pylori infection and gastric cancer in Asia. J Gastroenterol Hepatol. 2010;25(3):479-86.
Chey WD, Leontiadis GI, Howden CW, Moss SF. ACG Clinical Guideline: Treatment of Helicobacter pylori Infection. Am J Gastroenterol. 2017;112(2):212-39.
Heading RC. Prevalence of upper gastrointestinal symptoms in the general population: a systematic review. Scand J Gastroenterol Suppl. 1999;231:3-8.
Puttaraju S, Sreramaseshadri SRM. Study of upper gastrointestinal endoscopy in patients with gastrointestinal symptoms. Int Surg J. 2019;6:3595-9.
Jaka H, Koy M, Liwa A, Kabangila R, Mirambo M, Scheppach W, et al. A fibreoptic endoscopic study of upper gastrointestinal bleeding at Bugando Medical Centre in northwestern Tanzania: a retrospective review of 240 cases. BMC Res Notes. 2012;5:200.
Ahmad MM, Rahman M, Rumi AK, Islam S, Huq F, Chowdhury MF, et al. Prevalence of Helicobacter pylori in asymptomatic population--a pilot serological study in Bangladesh. J Epidemiol. 1997;7(4):251-4.
Muller LB, Fagundes RB, Moraes CC, Rampazzo A. Prevalence of Helicobacter pylori infection and gastric cancer precursor lesions in patients with dyspepsia. Arq Gastroenterol. 2007;44(2):93-8.
Misra V, Misra SP, Singh MK, Singh PA, Dwivedi M. Prevalence of H. pylori in patients with gastric cancer. Indian J Pathol Microbiol. 2007;50(4):702-7.
Bhattarai S. Clinical Profile and Endoscopic Findings in Patients with Upper Gastrointestinal Bleed Attending a Tertiary Care Hospital: A Descriptive Cross-sectional Study. JNMA J Nepal Med Assoc. 2020;58(226):409-415.
Pilotto A, Maggi S, Noale M, Franceschi M, Parisi G, Crepaldi G. Association of upper gastrointestinal symptoms with functional and clinical charateristics in elderly. World J Gastroenterol. 2011;17(25):3020-6.
