Synchronous breast and colon cancer in a young female: a single stage surgery


  • Mohammed Ayed Abushwemeh Department of General Surgery, Salmaniya Medical Complex, Bahrain
  • Nusrat Jabeen Department of General Surgery, Salmaniya Medical Complex, Bahrain
  • Asma Al Qaseer Department of General Surgery, Salmaniya Medical Complex, Bahrain
  • Mohamed Isa Department of General Surgery, Salmaniya Medical Complex, Bahrain
  • Amal Al Rayes Department of General Surgery, Salmaniya Medical Complex, Bahrain
  • Raed Al Marzooq Department of General Surgery, Salmaniya Medical Complex, Bahrain



Synchronous cancer, Second primary cancer, Colorectal cancer, Breast


Synchronous breast and colon cancers are rare, particularly in the absence of family history. Synchronous tumors should always be kept in mind during the staging workup for the primary malignancy. There are no definitive guidelines for the management of synchronous tumors, thus the involvement of tumour board multidisciplinary team is essential. We present a case of a young female patient who was diagnosed with synchronous breast and colon cancer. A handful of synchronous breast and colon cancer cases have been reported and operated at intervals, but up to our knowledge this is the first case operated simultaneously in a single stage surgery.  



Demandante CG, Troyer DA, Miles TP. Multiple primary malignant neoplasms: case report and a comprehensive review of the literature. Am J Clin Oncol 2003;26:79–83.

Bittorf B, Kessler H, Merkel S. Multiple primary malignancies: an epidemiological and pedigree analysis of 57 patients with at least three tumours. Eur J Surg Oncol 2001;27:302–13.

Higgins L, Robertson I, Khan W. Synchronous breast and colon cancer: factors determining treatment strategy. Bio Med J Case Rep 2013;2013.

Fisher CS, Wachtel MS, Margenthaler JA. Outcomes for patients who develop both breast and colorectal cancer. Ann Surg Oncol 2012;19:242–8.

Asaad A, Barron M, Rasheed N, Idaewor P, Al-Zawi AS. The Rare Diagnosis of Synchronous Breast and Colonic Cancers: A Case Report and Review of Literature. Cureus. 2021;13(2).

Kimura T, Iwagaki H, Fuchimoto S, Hizuta A, Orita K. Synchronous colorectal carcinomas. Hepato-gastroenterol. 1994;41(5):409-12.

Meijers-Heijboer H, Wasielewski M, Wagner A, Hollestelle A, Elstrodt F, van den Bos R, et al. The CHEK2 1100delC mutation identifies families with a hereditary breast and colorectal cancer phenotype. Am J Hum Genet. 2003;72(5):1308-14.

Ari A, Tatar C, Buyukasik K, Segmen O, Cakir C, Arikan S. Synchronous male breast and colon cancer presenting with ileus: A case report. Int J Surg Case Rep. 2016;28:31-3.

Weischer M, Bojesen SE, Ellervik C, Tybjærg-Hansen A, Nordestgaard BG. CHEK2* 1100delC genotyping for clinical assessment of breast cancer risk: meta-analyses of 26,000 patient cases and 27,000 controls. J Clinic Oncol. 2008;26(4):542-8.

Karayiannakis AJ, Kakolyris S, Kouklakis G, Chelis L, Bolanaki H, Tsalikidis C, et al. Synchronous breast and rectal cancers in a man. Case Rep Oncol. 2011;4(2):281-6.

Yetkin G, Celayir F, Akgun IE, Ucak R. Synchronous occurrence of primary breast carcinoma and primary colon adenocarcinoma. Case Rep Surg. 2017;2017.

Abdulla HA, Almarzooq R, Alrayes A. Synchronous breast and colon cancer: the importance of multidisciplinary team cancer meetings. Bio Med J Case Rep. 2019;12(12):e232680.






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