DOI: http://dx.doi.org/10.18203/2349-2902.isj20210512

Solitary polypoid ganglioneuroma in the sigmoid colon: a rare finding during colonoscopy

Madison Bowles

Abstract


Ganglioneuromas (GN) are rare, benign tumours of the autonomic nervous system which are seldom encountered in the gastrointestinal tract. They may occur as solitary lesions or more commonly as multiple lesions, also known as ganglioneuromatosis. Endoscopically they have no identifiable phenotypic characteristics and therefore diagnosis can only be confirmed through histological analysis. Microscopically they are composed of ganglion cells, nerve fibres and Schwann cells and show S-100 protein immunoreactivity. Clinically, there are no specific symptoms eluding towards the diagnosis of solitary ganglioneuromas of the gastrointestinal tract with most patients remaining asymptomatic. Due to their rarity, no guidelines current exists for solitary colonic GNs, however consensus exists that endoscopic resection is curative with no evidence of recurrence following total excision. This case gives an account of a solitary colonic ganglioneuroma in the sigmoid colon encountered during a screening colonoscopy in a 47-year-old male.


Keywords


Ganglioneuroma, Polypoid ganglioneuroma, Sigmoid colon, Colonoscopy, S100 tumour

Full Text:

PDF

References


Mendez I, Pereda T, Rodriguez F, Funez R, Sanchez A. Solitary colonic polypoid ganglioneuroma. Diagn Pathol. 2008;3:20.

Ofori E, Ona M, Ramai D, Huang T, Xiao P, Reddy M. Colonic Ganglioneuroma: A Rare Finding during Colorectal Cancer Screening. Case Rep Gastroenterol. 2017;11(2):434-9.

Abraham G, Prakash S. Solitary Colonic Ganglioneuroma: A Rare Incidental Finding of Hematochezia. Case Rep Gastrointest Med. 2015;2015:794985.

Alkhatib A, Tamara C. Isolated Colonic Polypoid Ganglioneuroma. J Am Osteopath Assoc 2013;113(5):433.

Ganglioneuroma. In: Lindberg M. Diagnostic Pathology: Soft Tissue Tumors (Second Edition), Elsevier. 2016;542-5.

Keshkin E, Yilmaz T, Sen G. A rare and incidental finding during colonoscopy: solitary polypoid ganglioneuroma: A case report. J Surg Med. 2019;3(3):274-5.

Voltaggio L, Montgomery E. Gastrointestinal tract spindle cell lesions-just like real estate, it’s all about location. Mod Pathol. 2015;28:S47-66.

Saire M, Parajuli D. Colonic Polypoid Ganglioneuroma. Practical Gastro. 2015;39(4).

Badrinath M, Mandru R, Lowe D, Manocha D, Achufusi T. Isolated Intestinal Ganglioneuroma Mimicking Small Bowel Crohn's Disease. ACG Case Rep J. 2019;6(7):e00114.

Surgical Pathology Criteria. Ganglioneuroma of the Gastrointestinal Tract. Available at http://surgpathcriteria.stanford.edu/gitumors/ganglioneuroma/printable.html. Accessed 9 November 2020.

Fiori E, Pozzessere C, Lamazza A, Leone G, Borrini F, Schillaci A et al. Endoscopic treatment of ganglioneuroma of the colon associated with a lipoma: a case report. J Med Case Rep. 2012;6:304.