DOI: http://dx.doi.org/10.18203/2349-2902.isj20210371

Analytic study of hormone receptor status of breast cancer patients visiting in a tertiary care hospital of North-West India

Vikas Kakkar, Arvind Kaushal, Swaraj Hanspal, Karanvir Singh, Anmol Randhawa, Harpreet Kaur

Abstract


Background: Increasing evidence shows the importance of young age, estrogen receptor (ER), progesterone receptor (PR) status, and HER-2 expression in patients with breast cancers. Breast tumors in younger age groups were more likely to be of higher grade, hormone receptor– negative, poorly differentiated, and aneuploid, and to have high S-phase fraction, abnormal expression of P53, greater extent of lymphovascular invasion, and over-expression of human epidermal growth factor receptor 2 (HER-2) than breast tumors in older age groups.  

Methods: We organised a retrospective study of 600 women diagnosed with breast cancer, who have been operated from 2016 to 2020. We evaluated age, size, hormone receptor status, HER-2 receptor status. Estrogen receptor and progesterone receptor status were evaluated by immunohistochemistry.

Results: Total 600 patient data was evaluated in this study. Rate of hormone positivity is more in older patients than in younger patients.  

Conclusions: In this study we conclude that the hormone positivity in younger patient is less as compared to older patients.  


Keywords


Hormone receptor, HER2/neu, Breast cancer, Tumor, Immunohistochemistry, ER, PR

Full Text:

PDF

References


American Cancer Society: Cancer Facts and Figures. 2004;3:10.

Albain KS, Allred DC, Clark GM. Breast cancer outcome and predictor of outcome: are there age differentials? J Natl Cancer Inst Monogr. 1994;16:35–42.

Kollias J, Elston CW, Ellis IO, Robertson JF, Blamey RW. Early-onset breast cancer-histopathological and prognostic considerations. Br J Cancer. 1997;75:1318–23.

Shannon C, Smith IE. Breast cancer in adolescents and young women. Eur J Cancer. 2003;39:2632–42.

Anders CK, Hsu DS, Broadwater G,et al.Young age at diagnosis correlates with worse prognosis and defines a subset of breast cancers with shared patterns of gene expression. J Clin Oncol. 2008;26:3324–30.

Gnerlich JL, Deshpande AD, Jeffe DB, Sweet A,White N, Margenthaler JA. Elevated Breast Cancer Mortality in Women Younger than Age 4s Compared with Older Women Is Attributed to Poorer Survival in Early-Stage Disease. J Am Coll Surg. 2009;208:341–7.

El Saghir NS, SeoudM, Khalil MK, et al. Effects of young age at presentation on survival in breast cancer. Bio Med Cent Cancer. 2006;6:194.

Gajdos C, Tartter PI, Bleiweiss IJ, Bodian C, Brower ST. Stage 0 to stage III breast cancer in young women. J Am Coll Surg. 2000;190:523–9.

Elkhuizen PH, van de Vijver MJ, Hermans J, Zonderland HM, van de Velde CJ, Leer JW. Local recurrence after breast-conserving therapy for invasive breast cancer: high incidence in young patients and association with poor survival. Int J Radiat Oncol Biol Phys. 1998;40:859–67.

Bollet MA, Sigal-Zafrani B, MazeauV, et al. Age remains the first prognos- tic factor for loco-regional breast cancer recurrence in young (,40 years) women treated with breast conserving surgery first. Radiother Oncol. 2007;82:272–80.

Vinh-Hung V, Verschraegen C, Promish DI, et al. Ratios of involved nodes in early breast cancer. Breast Cancer Res. 2004;6:680–8.

Veronesi U, Paganelli G, Viale G, et al. Sentinel Lymph Node Biopsy and Axillary Dissection in Breast Cancer: Results in a Large Series. J Natl Cancer Inst. 1999;91:368–73.

Jatoi I, Hilsenbeck SG, Clark GM, Osborne CK. Significance of Axillary Lymph Node Metastasis in Primary Breast Cancer. J Clin Oncol. 1999;17:2334–40.

Raina V, Bhutani M, Bedi R, Sharma A, Deo SVS, Shukla NK (2005) Clinical features and prognostic factors of early breast cancer at a major cancer center in North India. Ind J Cancer 42:40–5.

Desai SB, Moonim MT, Gill AK, Punia RS, Naresh KN, Chinoy RF (2000) Hormone receptor status of breast cancer in India: a study of 798 tumors. Breast. 9:267–70

Dunnwald LK, Rossing MA, Li CI (2007) Hormone receptor status, tumor characteristics, and prognosis: a prospective cohort of breast cancer patients. Breast Cancer Res. 9:R6

De la Rochefordiere A, Asselain B, Campana F, et al. Age as prognostic factor in premenopausal breast carcinoma. Lancet. 1993;341:1039–43.

Kroman N, Jensen MB, Wohlfahrt J, Mouridsen HT, Andersen PK, Melbye M. Factors influencing the effect of age on prognosis in breast cancer: population based study. Bio Med J. 2000;320:474–8.

Chia KS, Du WB, Sankaranarayanan R, et al. Do younger female breast cancer patients have a poorer prognosis? Results from a population-based survival analysis. Int J Cancer. 2004;108:761–5.