DOI: http://dx.doi.org/10.18203/2349-2902.isj20205823

Incidence of various urothelial malignancy in patients undergoing transurethral resection of bladder tumour in tertiary care hospital

Kamal Preet Kaur, Gurpreet Singh Bhangu, Darpan Bansal, Divya Julka

Abstract


Background: Urinary bladder lesions are a great health concern as it lies among the top ten most common cancers in the world. These range from benign, harmless lesions that do not recur to life threatening tumors. The present study was undertaken to study incidence of various urothelial cancer in patients undergoing transurethral resection of bladder tumor in tertiary care hospital, as the treatment, follow up and prognosis is highly variable with different subtypes of bladder cancer.

Methods: A hospital based descriptive cross-sectional study was conducted on all patients undergoing transurethral resection of bladder tumor from December 2018 to May 2020 in the Department of General Surgery of Sri Guru Ramdas Institute of Medical Sciences and Research, Amritsar. Based on World Health Organization (WHO) classification incidence of various urothelial malignancy was calculated.

Results: Out of 80 patients with growth urinary bladder, 4 patients (5% of total patient) were diagnosed as case of papilloma, 26 patients (32.5% of total patients) were diagnosed as low grade papillary urothelial carcinoma, 50 patients (62.5% of total patients) were of high grade papillary urothelial carcinoma. There were no case of PUNLMP in our study.

Conclusions: It can be concluded that majority of the patient undergoing transurethral resection of bladder tumor are diagnosed with high grade papillary carcinoma.

 


Keywords


Papilloma, Low grade TCC, High grade TCC

Full Text:

PDF

References


Bray F, Ferlay J, Soerjomataram I, Siegel RL, Torre LA, Jemal A. Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA: A Cancer Journal for Clinicians. 2018;68(6):394-424.

Pasin E, Josephson DY, Mitra AP, Cote RJ, Stein JP. Superficial bladder cancer: an update on etiology, molecular development, classification, and natural history. Rev Urol. 2008;10(1):31-43.

Witjes JA, Compérat E, Cowan NC. European Association of Urology. EAU guidelines on muscle-invasive and metastatic bladder cancer: summary of the 2013 guidelines. Eur Urol. 2014;65(4):778-92.

Society AC. Cancer facts & figures. American Cancer Society. 2016. http://www. cancer.org/acs/groups/content/@research/documents/document/ acspc-047079. Accessed on 20 October, 2020.

Bellmunt J, Orsola A, Leow JJ, Wiegel T, De Santis M, Horwich A. ESMO Guidelines Working Group. Bladder cancer: ESMO practice guidelines for diagnosis, treatment and follow-up. Ann Oncol. 2014;25(suppl 3):iii40-8.

Grignon DJ. The current classification of urothelial neoplasms. Mod Pathol. 2009;22(suppl 2):S60-9.

Pesch B, Nasterlack M, Eberle F, Bonberg N, Taeger D, Leng G et al. The role of haematuria in bladder cancer screening among men with former occupational exposure to aromatic amines. BJU International. 2011;108(4):546-52.

Krogsboll LT, Jorgensen KJ, Gotzsche PC. Screening with urinary dipsticks for reducing morbidity and mortality. Cochrane Database Syst rev. 2015;1:1-25.

Montironi R, Lopez-Beltran A, Mazzucchelli R, Bostwick DG. Classification and grading of the noninvasive urothelial neoplasms: Recent advances and controversies. J Clin Pathol. 2003;56:91-5.

Holmang S, Johansson SL. Stage Ta-T1 bladder cancer: The relationship between findings at first follow-up cystoscopy and subsequent recurrence and progression. J Urol. 2002;167:1634-7.

Aldousari S, Kassouf W. Update on the management of non-muscle invasive bladder cancer. Can Urol Assoc J. 2010;4(1):56-64.

Clark PE, Agarwal N, Biagioli MC. National Comprehensive Cancer Network. Bladder cancer. J Natl Compr Canc Netw. 2013;11(4):446-75.

Babjuk M, Böhle A, Burger M. EAU guidelines on non-muscleinvasive urothelial carcinoma of the bladder: update 2016. Eur Urol. 2017;71(3):447-61.

Brausi M, Olaru V. Management of high-risk non-muscle invasive bladder cancer. Minerva urologica e nefrologica. The Italian journal of urology and nephrology. 2012;64(4):255.

Petrelli F, Coinu A, Cabiddu M, Ghilardi M, Vavassori I, Barni S. Correlation of pathologic complete response with survival after neoadjuvant chemotherapy in bladder cancer treated with cystectomy: a metaanalysis. Eur Urol. 2014;65(2):350-7.

Chang SS, Bochner BH, Chou R, Dreicer R, Kamat AM, Lerner SP et al. Treatment of non-metastatic muscle-invasive bladder cancer: AUA/ASCO/ASTRO/SUO guideline. The Journal of Urology. 2017;198(3):552-9.

Ștefănescu ML, Tomescu PI, Forţofoiu MC, Stoica LE, Badea O, Mogoanta L et al. Urinary bladder tumors clinical and statistical retrospective study. Current Health Sciences Journal. 2018;44(1):64.

Agrawal A, Kalaswa R, Palekar HD. Analytical study of bladder tumor. International Surgery Journal. 2018;5(8):2782-7.

Thapa R, Lakhey M, Bhatta AD. Spectrum of histomorphological diagnosis in cystoscopic bladder biopsies. Journal of Pathology of Nepal. 2017;7(1):1062-5.

Goyal B, Rao S, Sahi R, Jaiswal S. A histopathologic study of urinary bladder tumors at tertiary care center in Mid-Western region of Nepal. Asian Journal of Medical Sciences. 2018;9(6):45-50.

Laishram RS, Kipgen P, Laishram S, Khuraijam S, Sharma DC. Urothelial tumors of the urinary bladder in Manipur: a histopathological perspective. Asian Pacific Journal of Cancer Prevention. 2012;13(6):2477-9.

Goyal VK, Vyas SP, Kothari DC. Spectrum of lesions in urinary bladder biopsies: histopathological study. Int J Dent Med Res. 2015;1(6):42-6.

Sathya M, Chinnaswamy P. Urinary bladder cancer: A clinicopathological and histological study. Journal of Medical Sciences. 2014;14(4):206-9.

Vaidya S, Lakhey M, KC S, Hirachand S. Urothelial tumours of the urinary bladder: a histopathological study of cystoscopic biopsies. Journal of the Nepal Medical Association. 2013;52(191):475-8.