Long term outcome of Wilms' tumor in tertiary care hospital

Authors

  • Jeevarathi T. Department of Pediatric Surgery, Institute of Child Health Hospital, Egmore, Chennai, Tamil Nadu, India
  • Gomathi Vadivelu Department of Pediatric Surgery, Stanley Medical College, Rayapuram, Chennai, Tamil Nadu, India

DOI:

https://doi.org/10.18203/2349-2902.isj20203998

Keywords:

Wilms' tumor, Long term outcome, Chromosomal abnormality, Intravenous urography, Treatment

Abstract

Background: Nephroblastoma, or Wilms’ tumor, is an embryonal tumor that develops from remnants of the immature kidney. It is the most common renal tumor of childhood. The aim is to analyze the long term outcome in Wilms’ tumor in perplex situations as double moiety and to correlate with multiple organ defects.

Methods: It is a combined perspective and retrospective study that pediatric urology outpatient department (OPD) at the Institute of Child Health and Hospital for Children, Madras Medical College, Chennai. The study included patients with Wilms, who attended the pediatric surgery during the ten years, from March 2008 to February 2011. The patients were subjected to detailed clinical examination and relevant investigations were performed.

Results: Among patients with stage I–II fumarate hydratase (FH) tumors, the relative risk (RR) of relapse and death were increased for loss of heterozygosity (LOH) 1p only (RR=2.2 for relapse; RR=4.0 for death), for LOH 16q only (RR=1.9 and RR=1.4), and LOH for both regions (RR=2.9 and RR=4.3) in comparison with patients lacking LOH at either locus.

Conclusions: Stage I and II have a good prognosis. Stage III and IV need close surveillance since they have a high rate of recurrence. Stage V has a bad prognosis. Stage IV Wilms need lung irradiation. Neoadjuvant chemotherapy reduces tumor spillage in stage III and IV.

 

Author Biography

Jeevarathi T., Department of Pediatric Surgery, Institute of Child Health Hospital, Egmore, Chennai, Tamil Nadu, India

assistant professor- regular publisher in medicp acdemay journal

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Published

2020-09-23

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Original Research Articles