The role of long non-coding RNAs in human carcinoma

Qiang Zhou, Minghua Deng, Jianping Gong


Long non-coding RNAs (LncRNAs) are usually longer than 200 nucleotides in length, which have 4 functions including signal, decoy, guide and scaffold in cells. Many studies have shown that the expression of LncRNAs is differentially between normal tissues and cancers, including hepatocellular carcinoma (HCC), bladder cancer, epithelial ovarian cancer, gastric cancer and other cancers, which suggests that alterations in the expression of LncRNAs could promote or inhibit tumor growth. However, the exact mechanisms by which LncRNAs play their roles in the normal and tumor cells remain unclear. This article reviews the role of LncRNAs in some common human carcinomas especially in HCC.


Long non-coding RNAs, Human carcinoma, HCC, Gene regulation

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