Non-clostridial gas gangrene of a diabetic foot with COVID-19 infection
DOI:
https://doi.org/10.18203/2349-2902.isj20203816Keywords:
Gas gangrene, Diabetic foot, COVID-19Abstract
Gas gangrene is a manifestation of soft tissue infection by clostridial group of bacteria. Non-clostridial gas gangrene is uncommon and seen rarely in diabetics. In the era of COVID-19 pandemic where COVID-19 itself induces hyperglycemia non clostridial gas gangrene may arise due to altered immunity. We present a case of non clostridial gas gangrene of lower limb in a middle aged person who was not a known diabetic. A brief case report with review of literature is presented.
References
Darke SG, King AM, Slack WK. Gas gangrene and related infection-classification, clinical features and aetiology, management and mortality: a report of 88 cases. Br J Surg. 1977;64:104-12.
Ghosh S, Bal AM, Malik I, Collier A. Fatal Morganella morganii bacteraemia in a diabetic patient with gas gangrene. J Med Microbiol. 2009;58:965-7.
Chiari, H. Zur Bakteriologie des septischen Emphysems. Prague Med Wochenschr. 1893;18:1-4.
Hitschmann F, Lindenthal OT. Ein weiterer Beitrag zur Pathologie und Aetiologie der Gangrene foudroyante. Wien Klin Wochenschr. 1900;13:1057-67.
Bessman AN, Wagner W. Non-clostridial gas gangrene: report of 48 cases and review of the literature. JAMA. 1975;233:958-63.
Stevens DL, Bryant AE. The role of clostridial toxins in the pathogenesis of gas gangrene. Clin Infect Dis. 2002;35(1):93-100.
Yang JK, Lin SS, Ji XJ, Guo LM. Binding of SARS coronavirus to its receptor damages islets and causes acute diabetes. Acta Diabetol. 2010;47:193-9.
Tao F, Tang X, Tao H, Luo Y, Cao H, Xiang W, et al. Surgical treatment of diabetic foot ulcers during the COVID-19 pandemic in China. J Diabetes Complications. 2020.
Magro C, Mulvey JJ, Berlin D, Nuovo G, Salvatore S, Harp J, et al. Complement associated microvascular injury and thrombosis in the pathogenesis of severe COVID-19 infection: a report of five cases. Transl Res. 2020;220:1-13.
Weinstein L, Barza MA. Gas gangrene. N Engl J Med. 1973;289:1129-31.