Renal profile of COVID-19 infected patients admitted in a tertiary care hospital in Western Rajasthan

Pradeep K. Sharma, Vikas Aggarwal, Naresh Sapariya, Shekhar Baweja, Rupesh Nagori, M. K. Chabbra


Background: A recent cluster of pneumonia cases all over the world including India, is caused by a novel beta coronavirus, the 2019 novel coronavirus (2019-nCoV). The objective of this study was to observe the effect on renal profiles at admission of these COVID-19 infected patients.

Methods: All the patients were admitted to Dr. S. N. Medical College and Hospital, Jodhpur, a tertiary care hospital of Western Rajasthan and were tested for COVID-19 by real time reverse transcription polymerase chain reaction assay of 2019-nCoVRNA. All data in relation to patients including blood renal profile were collected from data collection form from electronic medical records and history given by COVID-19 infected patients admitted.

Results: Out of total 300 COVID-19 patients, majority of patient were male i.e. 210 (70%) and majority of the patients 70% were below 60 years of age. The underlying diseases were present in 98 (32.67%) patients. Cough was the most common symptom (80%) followed by fever (72%) in out of 180 (60%) symptomatic patients. 64 (21.3%) patients had deranged renal function tests with abnormal blood urea nitrogen and serum creatinine. Overall, 56 patients (18.6%) without chronic kidney disease showed mild increase of BUN or serum creatinine. 35 patients (11.6%) had high blood urea nitrogen and 18 patients (6%) had raised creatinine.

Conclusions: In setting of COVID-19 infected patient’s presentation, renal profile remained essentially normal with deranged RFT seen in patients with comorbidities. Nevertheless, the renal function of patients with COVID-19 needs to be monitored regularly, especially in patients with elevated plasma creatinine.


Acute kidney injury, Chronic kidney disease, COVID-19, Renal profile

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Zhu N, Zhang D, Wang W, Li X, Yang B, Song J, et al. China Novel Coronavirus Investigating and Research Team. A novel coronavirus from patients with pneumonia in China, 2019. N Engl J Med. 2020;382(8):727-33.

Chen N, Zhou M, Dong X, Qu J, Gong F, Han Y, et al. Epidemiological and clinical characteristics of 99 cases of 2019 novel coronavirus pneumonia in Wuhan, China: a descriptive study. Lancet. 2020;395(10223):507-13.

Singbartl K, Joannidis M. Short-term effects of acute kidney injury. Crit Care Clin. 2015;31(4):751-62.

Mehta RL, Kellum JA, Shah SV, Molitoris BA, Ronco C, Warnock DG, et al. Acute kidney injury network: report of an initiative to improve outcomes in acute kidney injury. Crit Care. 2007;11:R31.

Kellum JA, Lameire N, Aspelin P, Barsoum RS, Burdmann EA, Goldstein SL, et al. Kidney disease: improving global outcomes (KDIGO) acute kidney injury work group. KDIGO clinical practice guideline for acute kidney injury. Kidney Int. 2012;2(1):1-38.

Lewis SM, Dirksen RF, Heitkemper MM, Bucher L, Harding M. Medical-surgical nursing: assessment and management of clinical problems. 9th ed. St. Louis, Missouri. London: Elsevier Health Sciences; 2014.

Wang L, Li X, Chen H, Yan S, Li D, Li Y, et al. Coronavirus disease 19 infection does not result in acute kidney injury: an analysis of 116 hospitalized patients from Wuhan, China. Am J Nephrol. 2020;51(5):343-8.

Khwaja A. KDIGO Clinical Practice Guidelines for Acute Kidney Injury. Nephron Clin Pract. 2012;120(4):c179-84.

Hu B, Zeng LP, Yang XL, Ge XY, Zhang W, Li B, et al. Discovery of a rich gene pool of bat SARS-related coronaviruses provides new insights into the origin of SARS coronavirus. PLoS Pathog, 2017;13(11):e1006698.

Song HD, Tu CC, Zhang GW, Wang SY, Zheng K, Lei LC, et al. Cross-host evolution of severe acute respiratory syndrome coronavirus in palm civet and human. Proc Nat Acad Sci USA. 2005;102(7):2430-5.

Haagmans BL, Al Dhahiry SH, Reusken CB, Raj VS, Galiano M, Myers R, et al. Middle East respiratory syndrome coronavirus in dromedary camels: an outbreak investigation. Lancet Infect Dis. 2014;14(2):140-5.

Azhar EI, El-Kafrawy SA, Farraj SA, Hassan AM, Al-Saeed MS, Hashem AM. et al. Evidence for camel-to human transmission of MERS coronavirus. N Engl J Med. 2014;370(26):2499-505.

Wang D, Hu B, Hu C, Zhu F, Liu X, Zhang J, Wang B, Xiang H, Cheng Z, Xiong Y, Zhao Y. Clinical characteristics of 138 hospitalized patients with 2019 novel coronavirus–infected pneumonia in Wuhan, China. JAMA. 2020;323(11):1061-9.

Huang C, Wang Y, Li X, Ren L, Zhao J, Hu Y, et al. Clinical features of patients infected with 2019 novel coronavirus in 312 Wuhan, China. Lancet. 2020;395(10223):497-506.

Jaillon S, Berthenet K, Garlanda C. Sexual dimorphism in innate immunity. Clin Rev Allerg Immunol. 2019;56:308-21.

Guan W, Ni Z, Hu Y, Liang W, Ou C, He J, et al. Clinical characteristics of 2019 novel corona virus infection in China. MedRxiv. 2020.

Zou X, Chen K, Zou J, Han P, Hao J, Han Z. Single-cell RNA-seq data analysis on the receptor ACE2 expression reveals the potential risk of different human organs vulnerable to 2019-nCoV infection. Front Med. 2020:1-8.