DOI: http://dx.doi.org/10.18203/2349-2902.isj20203258

Paget’s disease of the breast: a case series

Solomon N. Elenwo, Rollings S. Jamabo

Abstract


Paget’s disease of the nipple is a rare disease with a rather bizarre presentation which makes the diagnosis easily missed. Three cases are presented here with different modes of presentation and histological findings. A biopsy provided the definitive diagnosis in the three patients and the treatments offered was based on the histological findings - modified radical mastectomy and simple mastectomy for invasive carcinoma and carcinoma in-situ respectively.


Keywords


Paget’s disease, Breast, Nipple-areola complex, Case series

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References


Paget J. On the disease of the mammary areola preceding cancer of the mammary gland. St. Bartholomews Hosp Rep. 1874;10:87-9.

Kanitakis J. Mammary and extramammary Paget’s disease. J Eur Acad Dermatol Venereol. 2007;21:581-90.

Sakorafas GH, Blanchard K, Sarr MG, Farley DR. Paget’s disease of the breast. Cancer Treat Rev. 2001;27:9-18.

Tavassoli FA, Norwalk, Connecticut: Appletonand Lange. Pathology of the breast; 1999: 731-760.

Siponen E, Hukkinen K, Hekkil P, Joensuu H, Leidenius M. Surgical treatment in Paget’s disease of the breast. Am J Surg. 2010;200:241-6.

Martin VG, Pellettiere EV, Gress D, Miller AW. Paget’s disease in an adolescent arising in a supernumerary nipple. J Cutan Pathol. 1994;21:283-6.

Franceschini G, Masetti R, D’Ugo D, Palumbo F, D’Alba P, Mule A, et al. Synchronous bilateral Paget’s disease of the nipple associated with bilateral breast carcinoma. Breast J. 2005;11:355-6.

Ikeda DM, Helvie MA, Frank TS, Chapel KL, Andersson IT. Paget’s disease of the nipple: radiologic-pathologic correlation. Radiology. 1993;189:89-94.

Sawyer RH, Asbury DL. Mammographic appearances in Paget’s disease of the breast. Clin Radiol. 1994;49:185-8.

Yim JH, Wick MR, Philpott GW, Norton JA, Doherty GM. Underlying pathology in mammary Paget’s disease. Ann Surg Oncol. 1997;4:287-92.

Paone JF, Baker RR. Pathogenesis and treatment of Paget’s disease of the breast. Cancer. 1981;48:825-9.

Polgar C, Orosz Z, Kovacs T, Fodor J. Breast-conserving therapy for Paget’s disease of the nipple: a prospective European Organization for Research and Treatment of Cancer Study of 61 patients. Cancer. 2002;94:1904-5.

Dixon AR, Galea MH, Ellis IO, Elston CW, Blamey RW. Paget’s disease of the nipple. Br J Surg. 1991;78:722-3.