DOI: http://dx.doi.org/10.18203/2349-2902.isj20204117

A double blinded comparative study between omega 3 fatty acid infusion versus octreotide infusion in acute pancreatitis

Narayanswamy T., Supreeth K., Sridhar G.

Abstract


Background: Over decades the treatment of acute pancreatitis remains debatable with no common consensus on treatment guidelines, with some workers using octreotide infusion and some workers only relying on fluid therapy and symptomatic management. This double blinded comparative trial between omega 3 fatty acid infusion versus octreotide infusion and its response in cases of acute pancreatitis.

 Methods: This is a study where a double blinded randomised control trial was undertaken in proven cases of acute pancreatitis and patients were given omega 3 fatty acid infusion and octreotide infusion and the observations were documented and followed upon. 50 cases were given omega 3 fatty acid infusion and other 50 were given octreotide infusion and the clinical response, symptomatic improvement was assessed and compared using BISAP and Marshal scoring systems and lipase levels.

Results: Omega 3 fatty acid infusion was found to be highly significant as compared to octreotide in cases of acute pancreatitis in terms of clinical improvement, reduced hospital stay, and SIRS.

Conclusions: Omega 3 fatty acid infusion is the future in cases of acute pancreatitis which is cheap and easily available with no side effects and reduces the morbidity and mortality in acute pancreatitis with reduced hospital stay in turn resulting in overall reduced medical expenditure.


Keywords


Acute pancreatitis, Octreotide, Omega 3 fatty acid infusion, Pancreas

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References


Moggia E, Koti R, Belgaumkar AP, Fazio F, Pereira SP, Davidson BR, Gurusamy KS. Pharmacological interventions for acute pancreatitis. Cochrane Database of Systematic Reviews. 2017;(4):12-50.

Lankisch PG, Banks PA. Pancreatitis. 1st ed. New York: Springer;1998.

Garg PK, Tondon RK. Survey on chronic pancreatitis in the Asia-Pacific region. J Gastroenterol Hepatol. 2004;19:998-1004.

Rudraiah HGM, Kalke SV, Desai A. A novel treatment protocol in acute pancreatitis- the first double blinded comparative trial of omega 3 fatty acid infusion versus octreotide. Int Surg J. 2018; 5:4052-7.

Mayer K, Meyer S, Reinholz-Muhly M, Maus U, Merfels M, Lohmeyer J, et al. Short-time infusion of fish oil based lipid emulsions, approved for parenteral nutrition, reduces monocyte proinflammatory cytokine generation and adhesive interaction with endothelium in humans. J Immunol. 2003;171:4837-43.

Mori TA, Beilin LJ. Omega-3 fatty acids and inflammation. Curr Atheroscler Rep. 2004;6:461-7.