DOI: http://dx.doi.org/10.18203/2349-2902.isj20200521

Effect of α-adrenergic blockers silodosin in the management of distal ureteric calculus

Ranadheer S. Cholaraju, Karthik Aithal, P. S. M. Ameer Ali, Althaf Khan

Abstract


Background: Urinary calculus disease is one of the 3 most common urological diseases. It affects about 12% of the world population and has become a worldwide health problem. Of all the urinary tract stones 20% are ureteral stones, of which 70% are found in the distal ureter. The objective of the study is to study the effect of silodosin in the passage of calculi in the distal ureter compared to non-steroidal anti-inflammatory drugs (NSAIDs) (diclofenac sodium) and oral fluids.

Methods: This study included a total of 90 patients between the study period from October 2016 to October 2018. 45 patients were chosen randomly and advised to take plenty of oral fluids and treated with NSAIDs and the other 45 patients were treated with silodosin 8 mg HS for one month along with oral fluids and NSAIDs. After 1 month if the stone was passed successfully, it was confirmed with ultrasonography, if failed, advised for surgery.

Results: Majority of the patients were in the age group of 20-45 yrs. The mean size of the calculus was 5.60 cm on the right side and 5.71 cm on the left side. Out of the 45 patients who were on treatment with silodosin 35 patients had passed the calculi and 10 patients had no results with a success rate of 77.7%. In the 45 patients who were not on silodosin, 8 patients passed the calculi and 37 patients did not pass the calculi. 21 patients among the 45 underwent urethrorenoscopy.

Conclusions: Silodosin is an effective and safe drug in the management of calculi in the distal ureter.


Keywords


Alpha blocker, Silodosin, Ureteric stones, Ureteroscopy

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References


Sutton RA, Walker VR. Responses to hydrochlorothiazide and acetazolamide in patients with calcium stones: Evidence suggesting a defect in renal tubular function. N Engl J Med. 1980;302(13):709-13.

Morse RM, Resnick MI. Ureteral calculi: natural history and treatment in an era of advanced technology. J Urol. 1991;145(2):263-5.

Ehreth JT, Drach GW, Arnett ML, Barnett RB, Govan D, Lingeman J, et al. Extracorporeal shock wave lithotripsy: Multicenter study of kidney and upper ureter versus middle and lower ureter treatments. J Urol. 1994;152:1379-85.

Segura JW, Preminger GM, Assimos DG, Dretler SP, Kahn RI, Lingeman JE, et al. Ureteral stone s clinical guidelines panel summary report on the management of ureteral calculi. The American Urological Association. J Urol. 1997;158:1915-21.

Guimaraes S, Moura D. Vascular adrenoceptors: an update. Pharmacol Rev. 2001;53:319-56.

Resim S, Ekerbicer H, Ciftci A. Effect of tamsulosin on the number and intensity of ureteral colic in patients with lower ureteral calculus. Int J Urol. 2005;12(7):615-20.

Morita T, Wada I, Saeki H, Tsuchida S, Weiss RM. Ureteral urine transport:changes in bolus volume, peristaltic frequency, intraluminal pressure and volume of flow resulting from autonomic drugs J Urol. 1987;137(1):132-5.

Rizvi SAH, Naqvi SAA, Hussain Z, Hashmi A, Hussain M, Zafar MN, et al. The management of stone disease. Br Jr Urol. 2002;89:62.

Porpiglia F, Fiori C, Ghignone G, Vaccino D, Billia M, Morra I, et al. A second cycle of tamsulosin in patients with distal ureteric stones: a prospective randomized trial. BJUI. 2009;103(12):1700-3.

Puppo P, Ricciotti G, Bozzo W, Introini C. Primary Endoscopic treatment of ureteric calculi: A review of 378 cases. Euro Urol. 1999;36(1):48-52.

Morse RM, Resnick MI. Ureteral calculi: natural history and treatment in an era of advanced technology. J Urol. 1991;145(2):263-5.

Xizhao Sun, Lei He, Weihong Ge, Jianlin Lv. Efficacy of selective alpha 1D blocker Naftopidil as Medical Expulsive therapy for distal ureteral stones. J Urol. 2009;181:1716-20.