DOI: http://dx.doi.org/10.18203/2349-2902.isj20200278

Clinicopathological features and management of gastric cancer in Port Harcourt

Amabra Dodiyi Manuel, Okigbeye Danagogo

Abstract


Background: Gastric cancer is a relatively common cancer and has been documented as the 5th commonest cancer worldwide and the 3rd leading cause of cancer death. Surgery is the treatment of choice for operable cases while chemotherapy. It has a poor prognosis with a relative overall 5-year survival rate of 18%.

Methods: This is a retrospective study of all patients that presented with gastric cancer to University of Port Harcourt Teaching Hospital between 1st January 2008 to 31st December 2017. Data were extracted and analyzed using the Statistical Package for Social Sciences (SPSS).

Results: There were 14 males and 12 females seen within the study period making a male to female ratio of 1.2:1. Their ages ranged from 35 to 75 years with a mean of 54.7±4.8 years. The peak age incidence is in the 61-70-year age range. Four patients had curative surgery (D2 sub total gastrectomy) while 6 patients (23.1%) had D1 sub total gastrectomy. Post-operative complications occurred in 7 patients (26.9%). And the commonest was surgical site infection, seen in 4 patients (15.4%). Three patients died giving a mortality rate of 11.5%.

Conclusions: Most patients with gastric cancer present with advance disease. The choice of treatment should be based on patient’s fitness, survival benefit and after an accurate assessment of extent of disease.


Keywords


Gastric cancer, Management, Port Harcourt

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References


Ebili HO, Oluwasola AO, Akang EE, Ogunbiyi JO. Clinicopathological features of gastric carcinoma in Ibadan, Nigeria, 2000-2011. Nig J Med. 2015;56:126-31.

Khazaei S, Rezaeian S, Soheylizad M, Khazaei S, Biderafsh A. Global incidence and mortality rates of stomach cancer and the human development index: an ecological study. Asian Paci J Cancer Preven. 2016;17(4):1701-4.

Jemal A, Bray F, Center MM, Ferlay J, Ward E, Forman D. Global cancer statistics. Cancer J Clini. 2011;61(2):69-90.

Elmajjaoui S, Ismaili N, Zaidi H, Elkacemi H, Hassouni K, Kebdani T, et al. Epidemiological, clinical, pathological, and therapeutic aspects of gastric cancer in Morocco. Clin Cancer Invest J. 2014;3(1):3.

Asplund J, Kauppila JH, Mattsson F, Lagergren J. Survival trends in gastric adenocarcinoma: a population-based study in Sweden. Annal Surg Oncol. 2018;25(9):2693-702.

Satti MB, Al-Quorain AA, Al-Gindan YM, Al Hamdan AA, Al-Idrissi HY. Gastric malignancy: clinicopathologic spectrum and relationship to Helicobacter pylori infection. Saudi J Gastroenterol. 2005;11(3):149.

Afridi SP, Bano F. Pattern and presentation of carcinoma stomach. J Coll Phy Surg Pak. 2011;21(3):161-3.

Ahmed A, Ukwenya AY, Makama JG, Mohammad I. Management and outcome of gastric carcinoma in Zaria, Nigeria. African Health Sci. 2011;11(3):353-61.

Osime OC, Momoh MI, Irowa OO, Obumse A. Gastric carcinoma-a big challenge in a poor economy. J Gastroint Cancer. 2010;41(2):101-6.

Park JM, Kim YH. Current approaches to gastric cancer in Korea. Gastrointest Cancer Res. 2008;2:137-44.

Bakari AA, Ibrahim AG, Gali BM, Dogo D, Nggada HA. Pattern of gastric cancer in North-eastern Nigeria: a clinicopathological study. J Chinese Clin Med. 2010;5(4):211-5.

Sabageh D, Ojo OS, Adelusola KA. Gastric carcinoma: A review of the histopathological features of cases seen at Ile-Ife, Nigeria. Annal Trop Pathol. 2010;1(1):27.

Komolafe AO, Ojo OS, Olasode BJ. Gastric malignancies and associated pre-malignant lesions in a teaching hospital in South West Nigeria. Afri J Biotechnol. 2008;7(13):2104-11.

Alatise OI, Lawal OO, Adesunkanmi AK, Agbakwuru AE, Arigbabu OA, Ndububa DA, et al. Clinical pattern and management of gastric cancer in Ile-Ife, Nigeria. Arab J Gastroenterol. 2007;8(4):123-6.

Hartgrink HH, Van de Velde CJ, Putter H, Bonenkamp JJ, Klein Kranenbarg E, Songun I, et al. Extended lymph node dissection for gastric cancer: who may benefit? Final results of the randomized Dutch gastric cancer group trial. J Clin Oncol. 2004;22(11):2069-77.

Wang Z, Chen JQ. Imaging in assessing hepatic and peritoneal metastases of gastric cancer: a systematic review. BMC Gastroenterol. 2011;11(1):19.

Degiuli M, Sasako M, Calgaro M, Garino M, Rebecchi F, Mineccia M, et al. Morbidity and mortality after D1 and D2 gastrectomy for cancer: interim analysis of the Italian Gastric Cancer Study Group (IGCSG) randomised surgical trial. Eur J Surg Oncol (EJSO). 2004;30(3):303-8.

Xue Y, Wei Y. The relationship of prognosis to surgery and pathologic characteristics of stage IV (M0) gastric cancer patients. Chinese J Cancer. 2010;29(4):355-8.

Griniatsos J, Gakiopoulou H, Yiannakopoulou E, Dimitriou N, Douridas G, Nonni A, et al. Routine modified D2 lymphadenectomy performance in pT1-T2N0 gastric cancer. World J Gastroenterol. 2009;15(44):5568.

Takeuchi H, Kitagawa Y. Is lymphadenectomy a predictor or savior for patients with gastric cancer?. Annal Surg Oncol. 2010;17(5):1257-8.

Polkowski W, van Sandick JW, Offerhaus GJ, ten Kate FJ, Mulder J, Obertop H, et al. Prognostic value of Lauren classification and c-erbB-2 oncogene overexpression in adenocarcinoma of the esophagus and gastroesophageal junction. Annal Surg Oncol. 1999;6(3):290-7.

Kabir MA, Barua R, Masud H, Ahmed DS, Islam MM, Karim E, et al. Clinical presentation, histological findings and prevalence of Helicobacter pylori in patients of gastric carcinoma. Faridpur Med Coll J. 2011;6(2):78-81.

Yu J, Zhao Q. The demographic characteristics of histological types of gastric cancer with gender, age, and tumor location. J Gastroint Cancer. 2009;40(3-4):98.

Popiela T, Kulig J, Kolodziejczyk P, Sierzega M. Changing patterns of gastric carcinoma over the past two decades in a single institution: clinicopathological findings in 1557 patients. Scand J Gastroenterol. 2002;37(5):561-7.

Lundegårdh G, Lindgren A, Rohul A, Nyren O, Hansson LE, Bergström R, et al. Intestinal and diffuse types of gastric cancer: secular trends in Sweden since 1951. Bri J Cancer. 1991;64(6):1182.

Kaneko S, Yoshimura T. Time trend analysis of gastric cancer incidence in Japan by histological types, 1975-1989. Bri J Cancer. 2001;84(3):400.

Sah BK, Chen MM, Yan M, Zhu ZG. Reoperation for early postoperative complications after gastric cancer surgery in a Chinese hospital. World J Gastroenterol: WJG. 2010;16(1):98.

Oluwasola AO, Ogunbiyi JO. Gastric cancer: aetiological, clinicopathological and management patterns in Nigeria. Nigerian J Med: J National Assoc Resid Doc Nigeria. 2003;12(4):177-86.

Mabogunje OA, Lawrie JH. Surgical management of advanced gastric carcinoma in Zaria, Nigeria. Eur J Surg Oncol. 1985; 11:361-4.

Arigbagbo AO. Gastric cancer in Nigeria. Trop Doct. 1998;18:13-5.

Alatise OI, Lawal OO, Adesunkanmi AK, Agbakwuru AE, Arigbabu OA, Ndububa DA, et al. Clinical pattern and management of gastric cancer in Ile-Ife, Nigeria. Arab J Gastroenterol. 2007;8(4):123-6.