Helicobacter pylori among the cases of gastritis: a one year study at a tertiary care hospital of South India

Authors

  • Ayathu V. S. Sai Mahesh Department of General Surgery, Narayana Medical College, Chinthareddypalem, Nellore, Andhra Pradesh
  • Shyam Sundar Tandri Department of General Surgery, Narayana Medical College, Chinthareddypalem, Nellore, Andhra Pradesh

DOI:

https://doi.org/10.18203/2349-2902.isj20195215

Keywords:

Helicobacter pylori, Gastritis, Rapid urease test, Endoscopy

Abstract

Background: Gastritis is one of the commonest clinical conditions encountered by a physician. The most common cause is said to be infection with Helicobacter pylori. The present study was aimed to diagnose the prevalence of H. pylori infection among the cases of gastritis and its correlation with histopathological findings and associated rapid urease test.

Methods: A one year prospective study at a tertiary care hospital was conducted and all cases of gastritis were included and socio demographic data, clinical complaints and duration were noted. Endoscopy was performed on all cases. Biopsy was performed histopathological examination with staining and graded by Houston-updated Sydney system. Rapid urease test was performed and findings noted.

Results: 325 cases with 215 male and 110 female cases were included. 26.15% were in age group of more than 60 years and number of cases increased with age. Mean age of study participants was 39.12±2.8 years and heart burn was the common complaint in the study cases. 81.54% of the cases revealed endoscopic gastritis on endoscopy and hyperaemia was commonest. 83.69% were positive by rapid urease test. Rapid urease test is more sensitive than histological staining in confirmation of H. pylori infection.

Conclusions: To conclude on the present study, the prevalence of H. pylori infection is on a global rise and appropriate measures to reduce the prevalence is quite an urgent necessity. Histopathological interpretation of gastric biopsies is a reliable indicator of H. pylori infection as well as gastritis grading according to the Sydney grading system.

Author Biographies

Ayathu V. S. Sai Mahesh, Department of General Surgery, Narayana Medical College, Chinthareddypalem, Nellore, Andhra Pradesh

Assistant professor, Department of General surgery

Shyam Sundar Tandri, Department of General Surgery, Narayana Medical College, Chinthareddypalem, Nellore, Andhra Pradesh

Assistant professor, Department of General surgery

References

Siao D, Somsouk M. Helicobacter pylori: evidence-based review with a focus on immigrant populations. J Gen Intern Med. 2014;29:520-8.

Agbor NE, Esemu SN, Ndip LM, Tanih NF, Smith SI, Ndip RN, et al. Helicobacter pylori in patients with gastritis in West Cameroon:prevalence and risk factors for infection. BMC Res Notes. 2011;11;559-62.

Veldhuyzen van Zanten SJ, Sherman PM. Helicobacter pylori infection as a cause of gastritis, duodenal ulcer, gastric cancer and nonulcer dyspepsia:a systematic overview. CMAJ. 1994;150(2):177-85.

Dixon MF, Genta RM, Yardley JH, Gorrea P. Classification and grading of gastritis. The updated Sydney system Am J Surg Pathol. 1996:20(4):1161-81.

Bello AK, Umar AB, Borodo MM. Prevalence and risk factors for helicobacter pylori infection in gastroduodenal diseases in Kano, Nigeria. Afr J Med Health Sci. 2018;17:41-6.

Sharma SK, Maharjan DK, Thapa PB. Hospital based analytic study of peptic ulcer disease in patients with dyspeptic symptoms. Kathmandu Univ Med J. 2009;7:135-8.

Böhmer CJ, Klinkenberg-Knol EC, Kuipers EJ, Niezen-de Boer MC, Schreuder H, Schuckink-Kool F, et al. The prevalence of Helicobacter pylori infection among inhabitants and healthy employees of institutes for the intellectually disabled. Am J Gastroenterol. 1997;92:1000-4.

Kouitcheu Mabeku LB, Noundjeu Ngamga ML, Leundji H. Potential risk factors and prevalence of Helicobacter pylori infection among adult patients with dyspepsia symptoms in Cameroon. BMC Infect Dis. 2018;(18);278-86.

Mandal AK, Kafle P, Puri P, Chaulagai B, Sidhu JS, Hassan M, et al. An association of Helicobacter pylori infection with endoscopic and histological findings in the Nepalese population. J Family Med Prim Care. 2019;8:1227-31.

Thapa R, Lakhey M, Yadav PK, Kandel P, Aryal C, Subba K. Histopathological study of endoscopic biopsies. J Nepal Med Assoc. 2013;52:354-6.

Shrestha R, Koirala K, Raj KS, Batajoo KH. Helicobacter pylori infection among patients with upper gastrointestinal symptoms: Prevalence and relation to endoscopy diagnosis and histopathology. J Family Med Prim Care. 2014;3:154-8.

Uotani T, Graham DY. Diagnosis of Helicobacter pylori using the rapid urease test. Ann Transl Med. 2015;3(1):9.

Foroutan M, Loloei B, Irvani S, Azargashb E. Accuracy of rapid urease test in diagnosing Helicobacter pylori infection in patients using NSAIDs. Saudi J Gastroenterol. 2010;16:110-2.

Khan MQ, Alhomsi Z, Al-Momen S, Ahmad M. Endoscopic features of Helicobacter pylori induced gastritis. Saudi J Gastroenterol. 1999;5:9-14.

Rugge M, Meggio A, Pennelli G, Piscioli F, Giacomelli L. Gastritisstaging in clinical practice:the OLGA staging system. Gut. 2007;56:631-6.

Chen XY, Liu WZ, Shi Y, Zhang DZ, Xiao SD, Tytgat GNJ. Helicobacter pylori associated gastric diseases and lymphoid tissue hyperplasia in gastric antral mucosa. J Clin Pathol. 2002;55:133-7.

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Published

2019-11-26

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Original Research Articles