DOI: http://dx.doi.org/10.18203/2349-2902.isj20195962

Gender specific variation in risk factors of gallstone disease among adult patients

Deepak Dhamnetiya, Manish K. Goel, Balraj Dhiman, Om P. Pathania

Abstract


Background: Gallstone disease (GSD) is a common gastrointestinal disease diagnosed in patients presented with abdominal pain. The present study was aimed to find the association between demographic, personal, behavioural and dietary factors and GSD by gender among adult population for suggesting specific gender wise intervention to control GSD.

Methods: Case-control study was conducted in 120 cases and same number of controls. Data was collected on a self-designed pretested “interview schedule”. To measure the strength of association OR was calculated by matched pair analysis using McNemar’s test.

Results: Among 120 study subjects, 83 cases were females and 37 were males. Strength of association was found to be significantly higher for family h/o GSD in females (OR=8), physical inactivity (OR=8), waist-hip ratio (OR=4.2), calorie intake more than recommended dietary allowance (RDA) (OR=2.09), and diabetes (OR=4) as compare to males OR=3, OR=2.8, OR=2.5, OR=1.43, OR=2.33 respectively.

Conclusions: Family h/o GSD, physical inactivity, high waist-hip ratio, calorie and fat intake more than RDA, protein intake less than RDA, hypertension and diabetes were found to be potential risk factors for the development of GSD in females. Consumption of smokeless tobacco, physical inactivity, non-vegetarian diet and intake of fats more than RDA were risk factors for GSD in males.


Keywords


Gallstone disease, Behavioural and dietary risk factors, Case control study, Matched pair analysis

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References


Hung SH, Liao KF, Lai SW, Li CI, Chen WC. Risk factors associated with symptomatic cholelithiasis in Taiwan: a population-based study. BMC Gastroenterol. 2011;11:111-6.

Khuroo MS, Mahajan R, Zargar SA, Javid G, Sapru S. Prevalence of biliary tract disease in India: a sonographic study in adult population in Kashmir. Gut. 1989;30:201-5.

Unisa S, Jagannath P, Dhir V, Khandelwal C, Sarangi L, Roy TK. Population‐based study to estimate prevalence and determine risk factors of gallbladder diseases in the rural Gangetic basin of North India. HPB. 2011;13(2):117-25.

Sachdeva S, Khan Z, Ansari MA, Khalique N, Anees A. life style and gall stone disease: Scope for primary prevention. Indian J Community Med. 2011;36:263-7.

Zamani F, Sohrabi M, Alipour A, Motamed N, Saeedian FS, Pirzad R, et al. Prevalence and risk factors of cholelithiasis in Amol city, northern Iran: a population based study. Arch Iranian Med. 2014;17:750-4.

Bilal M, Haseeb A, Saad M, Ahsan M, Raza M, Ahmed A, et al. The Prevalence and Risk Factors of Gallstone among Adults in Karachi, South Pakistan: A Population-Based Study. Global J Health Sci. 2016;9:106.

Sun H, Tang H, Jiang S, Zeng L, Chen EQ, Zhou TY, et al. Gender and metabolic differences of gallstone diseases. World J Gastroenterol. 2009;15(15):1886-91.

Hsu HY, Huang CY, Hwang LC. Sex difference of the predictive value of BMI, waist circumference and percentage body fat mass for gallstone disease. Br J Nutr. 2019;121:955–60.

Liu T, Wang W, Ji Y, Wang Y, Liu X, Cao L, et al. Association between different combination of measures for obesity and new onset gallstone disease. PLoS ONE. 2018;13(5):e0196457.

Gyedu A, Adae-Aboagye K, Badu-Peprah A. Prevalence of cholelithiasis among persons undergoing abdominal ultrasound at the KomfoAnokye Teaching Hospital, Kumasi, Ghana. Afr Health Sci. 2015;15(1):246–52.

National Institute of Nutrition (Indian Council of Medical Research). Dietary Guidelines for Indians-A Manual. Available at http://ninindia.org/Dietary GuidelinesforNINwebsite.pdf. Assessed on 9th August 2018.

World Health Organization. The Asia Pacific Perspective; Redefining obesity and its treatment. Available at http://www.wpro.who.int/nutrition/ documents/docs/Redefiningobesity.pdf. Assessed on 17th December 2014.

Layde PM, Vessey MP, Yeates D. Risk factors for gallbladder disease: a cohort study of young women attending family planning clinics. J Epidemiol Community Health. 1982;36:274-8.

Malhotra SL. Epidemiological study of cholelithiasis among railroad workers in India with special reference to causation. Gut. 1968;9:290-5.

Al-Kayatt MK, Al-Youzbaki DB. Sociological Risk Factors in Development of Gallstones for Childbearing Age Women. Iraqi J Comm Med. 2008;2:97-103.

Gomati A, Elafi S, Rafe H, Abimbola EO, Willido AA, Sahitha R. Study on the Risk factors for Gallbladder diseases in El-khoms Tertiary Care Hospital, Libya. Asian J Trop Med Public Health. 1990;2:1-4.

Duque MX, Moran S, Salmeron-Castro J, Kageyama ML, Rodriguez-Leal G, Ramos ME, et al. Inverse association between plasma cholesterol and gallstone disease. Arch Med Res. 1999;30:190–7.

Figueiredo JC, Haiman C, Porcel J, Buxbaum J, Stram D, Tambe N, et al. Sex and ethnic/racial-specific risk factors for gallbladder disease. BMC Gastroenterol. 2017;17:153.

Shabanzadeh DM, Holmboe SA, Sorensen LT, Linneberg A, Andersson AM, Jørgensen T. Are incident gallstones associated to sex-dependent changes with age? A cohort study. Andrology. 2017;5:931-8.

Scragg RKR, MicMichael AJ, Baghurst PA. Diet, alcohol, and relative weight in gall stone disease: a case-control study. BMJ. 1984;288:1113-9.

Stender S, Nordestgaard BG, Tybjaerg-Hansen A. Elevated body mass index as a causal risk factor for symptomatic gallstone disease: a Mendelian randomization study. Hepatology. 2013;58:2133-41.

Kim HS, ChoSK, Kim CS, Park JS. Big data and analysis of risk factors for gallbladder disease in the young generation of Korea. PLoSONE 2019:14(2):e0211480.

Kim SB, Kim KH, Kim TN, Jung MK, Cho CM, Lee YS, et al. Sex differences in prevalence and risk factors of asymptomatic cholelithiasis in Korean health screening examinee: a retrospective analysis of a multicenter study. Medicine. 2017;96(13):e6477.

Zamani F, Sohrabi M, Alipour A, Motamed N, Saeedian FS, Pirzad R, et al. Prevalence and risk factors of cholelithiasis in Amol city, northern Iran: a population based study. Arch Iranian Med. 2014;17:750-4.