Single dose versus multiple dose prophylactic antibiotic in laparoscopic cholecystectomy: a comparative study


  • Pinakin K. Sutariya Department of Surgery, GMERS Medical College, Sola, Gujarat
  • Pukur I. Thekdi Department of Surgery, C U Shah Medical College and Hospital, Surendranagar, Gujarat



Single dose vs. multiple dose, Antibiotic prophylaxis, Laparoscopic cholecystectomy


Background:Our study is aimed to compare the impact of single vs. multiple dose of antibiotic in laparoscopic cholecystectomy in terms of post-operative infection related complications.

Methods: The present study was prospective and longitudinal. Protocol of the procedure was formed along with Performa, Patient Information Sheet and Informed Consent Form. This study was carried out from January 2013 to June 2015 in surgery department of a secondary care hospital of Gujarat state. Total 180 patients who were admitted for elective laparoscopic cholecystectomy were included in our study. The patients were randomly divided in two equal groups: single dose (SD) group and multiple dose (MD) group, comprising of 90 patients in each group. SD group was given ceftriaxone (2 gm) intravenously at the time of induction of anaesthesia. Whereas, MD group was given ceftriaxone (2 gm) intravenously at the time of induction of anaesthesia followed by ceftriaxone (1 gm) intravenously twice a day for two days post-operatively.

Results: In single dose antibiotic group, total post-operative infection rate was 4.4% and that in multiple dose groups was found to be 3.3%. Data was analysed with Chi- square test and the difference in the rate of SSI in both the groups was found statistically insignificant.

Conclusion: The rate of post-operative SSI after single dose antibiotic intravenously at induction of anaesthesia is comparable with that of multiple dose antibiotics. So single dose antibiotic regimen can be safely practiced in elective laparoscopic cholecystectomy.






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