The pattern of urine cytology among patients with clinical diagnosis of bladder tumor in a tertiary hospital northwest Nigeria
Keywords:Urine cytology, Bladder tumour, Cystoscopy, Biopsy
Background: Urine cytology is a simple, safe, non-invasive and cheap investigation that is used as adjunct to cystoscopy in the diagnosis of bladder cancer. Its low sensitivity is a major limitation against its use as a sole diagnostic test for bladder cancer. The objective of this study was to determine the pattern of urine cytology seen in patients with clinical diagnosis of bladder tumour in our practice.
Methods: This is a retrospective study of patients with clinical diagnosis of bladder tumour that had urine cytology in our centre. The age and gender of the patients, number of urine cytology per patient per year and cytologic diagnosis were analysed using the SPSS 20.
Results: During the period under review, a total of 512 urine cytology was done for patients with clinical diagnosis of bladder tumour. The age range of the patients was 6 to 90 years with modal age of 60 years. 457 (89.3%) were males while 54 (10.5%) were females and 1 (0.2%) was unspecified. Male to female ratio was 8.5:1. The highest number of urine cytology was done in 2013 with 64 (12.5%) while the least number was 1 (0.2%) recorded in 2001 and 2003. Only 68 (13.3%) specimens were reported to be malignant while 245 (47.9%) were reported as negative representing the most common cytological diagnosis in the study.
Conclusions: Although urine cytology is useful in the diagnostic workup of patients with bladder mass, it is unlikely it would supplant cystoscopy and biopsy in the diagnosis of bladder cancer.
Konety BR, Carroll PR. Urothelial carcinoma: cancers of the bladder, ureter and renal pelvis. In: McAninch JW, Lue TF, eds. Smith and Tanagho’s General Urology. 18th ed. New York: McGraw-Hill Medical; 2013: 310-329.
Chawla N, Mehta R, Tewari K. Role of urine cytology in bladder neoplasm- cytopathological correlation and review of literature. J Mar Med Soc. 2018;20:27-30.
Mungadi IA, Malami SA. Urinary bladder cancer and schistosomiasis in North-Western Nigeria. West Afr J Med. 2007;26:226-9.
Van Rhijn BWG, Van der Poel HG, Van der Kwast TH. Cytology and Urinary Markers for the Diagnosis of Bladder Cancer. Eur Urol. 2009;8:536-41.
Caraway NP, Katz RL. A review on the current state of urine cytology emphasizing the role of fluorescence in situ hybridization as an adjunct to diagnosis. Cancer Cytopathol. 2010;118:175-83.
Sahabi SM, Abdullahi K. Abstract 1212: urinary bladder cancer in Sokoto, Northwestern Nigeria: a 10-year histopathological review. Cancer Res. 2018;78:1212.
Mansoor I. Analysis of urine cytology at a community hospital. J Ayub Med Coll Abbottabad. 2003;15:20-3.
Case B, Brimo F, Auger M, Aprikian A, Kassouf W, Vollmer RT. Accuracy of urine cytology and the significance of an atypical category. Am J Clin Pathol. 2009;132:785-93.
Brimo F, Vollmer RT, Case B, Aprikian A, Kassouf W, Auger M. Accuracy of urine cytology and the significance of an atypical category. Am J Clin Pathol. 2009;132:785-93.
Wild PJ, Fuchs T, Stoehr R, Zimmermann D, Frigerio S, Padberg B, et al. Detection of urothelial bladder cancer cells in voided urine can be improved by a combination of cytology and standardized microsatellite analysis. Cancer Epidemiol Biomarkers Prev. 2009;18(6):1798-806.
Planz B, Synek C, Deix T, Bocking A, Marberger M. Diagnosis of bladder cancer with urinary cytology, immunocytology and DNA-image-cytometry. J Urol. 1998;159:384-8.
Planz B, Jochims E, Deix T, Caspers HP, Jakse G, Boeckin A. The role of urinary cytology for detection of bladder cancer. Eur J Surg Oncol. 2005;31:304-8.
Obiorah CC, Ofuru VO. Urine cytology outcome in a tertiary health institution in Nigeria. Eur J Pharm Med Res. 2017;4:87-92.
Curling M, Broome G, Hendry WF. How accurate is urine cytology?. J R Soc Med. 1986;79:336-8.
Kehinde EO, Al-Mulla F, Kapila K, Anim JT. Comparison of the sensitivity and specificity of urine cytology, urinary nuclear matrix protein-22 and multitarget fluorescence in situ hybridization assay in the detection of bladder cancer. Scand J Urol Nephrol. 2011;45:113-21.
Malami SA, Bindiga UH, Abimiku BA, Mungadi IA, Abdullahi AD, Dauda A, et al. A descriptive retrospective study of the pattern of bladder cancer of the pattern of malignant diseases in Sokoto, North Western Nigeria (1999-2004). J Med Sci. 2007;7:1033-8.