DOI: http://dx.doi.org/10.18203/2349-2902.isj20191866

The pattern of urine cytology in a tertiary health care facility Northwest Nigeria

Abdullahi Abdulwahab-Ahmed, Kabiru Abdullahi, Mohammed A. Umar, Ngwobia P. Agwu, Abubakar S. Muhammad, Abdullahi Khalid

Abstract


Background: Urine cytology is an important investigation in the management of urothelial cancer. It is particularly an important test in the management of urinary tract cancers because of its non-invasive nature. Objective of study to review our practice of urine cytology as a diagnostic tool in the management of urinary tract pathology.

Methods: A seventeen years retrospective study from 1st January, 2001 to 31st December, 2017 where records of patients who had urine cytology in Usmanu Danfodio University Teaching Hospital (UDUTH), Sokoto, Nigeria were reviewed and data was extracted and analyzed using the SPSS 20.

Results: Of the 766 specimens, representing 10.1% of all cytology done in UDUTH (7,554) during the period under review, the highest number of urine cytology was done in 2013 (12%). The age range of the patients was between 2 to 90 years with modal age of 60 years. Majority of the patients were between the ages of 51 to 60 years (24.7%) and male to female ratio was 6.3:1. The commonest indication for urine cytology was bladder tumour (66.8%). However, the commonest cytological diagnosis was negative (44.6%) while 19.3% showed Non Specific Chronic Inflammation and only 77 specimens were malignant representing 10.1% of the specimen.

Conclusions: Despite its variable sensitivity, urine cytology remains a useful tool in evaluating suspected bladder malignancies and can serve as an adjunct to cystoscopy in these cases.


Keywords


Urine cytology, Urothelial cancer, Bladder tumour, Schistosomiasis

Full Text:

PDF

References


Alameddine M, Nassir A. The influence of urine cytology on our practice. Urology Annals. 2012;4(2):80-3.

Kehinde EO, Al-Mulla F, Kapila K, Anim JT. Comparison of the sensitivity and specificity of urine cytology, urinary nuclear matrix protein-22 and multitarget fluorescence in situ hybridization assay in the detection of bladder cancer. Scandinavian J Urol Nephrol. 2011;45(2):113-21.

Yafi FA, Brimo F, Steinberg J, Aprikian AG, Tanguay S, Kassouf W. Prospective analysis of sensitivity and specificity of urinary cytology and other urinary biomarkers for bladder cancer. Urologic Oncology: Seminars and Original Investigations. 2015;33(2):66.e25-66.e31.

Mansoor I, R Calam R, Al-Khafaji B. Role of urinary NMP-22 combined with urine cytology in follow-up surveillance of recurring superficial bladder urothelial carcinoma. 2008 Feb;30(1):25-32.

Rathert P, Roth S. Indications for Urinary Cytology. In: Rathert P, Roth S. Urinary Cytology. Berlin, Springer; 1993:9-13.

Brimo F, Vollmer RT, Case B, Aprikian A, Kassouf W, Auger M. Accuracy of urine cytology and the significance of an atypical category. Ame J Clin Pathol. 2009;132(5):785-93.

Planz B, Jochims E, Deix T, Caspers HP, Jakse G, Boecking A. The role of urinary cytology for detection of bladder cancer. Euro J Surg Oncol. 2005;31(3):304-8.

Bastacky S, Ibrahim S, Wilczynski SP, Murphy WM. The accuracy of urinary cytology in daily practice. Cancer. 1999;87(3):118-28.

Nabi G, Greene DR, O’Donnell M. How Important is Urinary Cytology in the Diagnosis of Urological Malignancies? European Urol. 2003;43(6):632-6.

Mungadi IA, Malami SA. Urinary bladder cancer and schistosomiasis in North-Western Nigeria. West African J Med. 2007;26(3):226-9.

Sahabi SM, Abdullahi K. Abstract 1212: Urinary bladder cancer in Sokoto, Northwestern Nigeria: A 10-year histopathological review. Cancer Res. 2018;78(13 Supplement):1212.

Chinedu OC, Obisike OV. Urine cytology outcome in a tertiary health institution in Nigeria. European J Pharma Med Res. 2017;4(11):87-92.

Manna AK, Sarkar M, Bandyopadhyay U, Chakrabarti S, Pathak S, Sarkar DK. Cytological and morphometric study of urinary epithelial cells with histopathological correlation. Indian J Surg. 2014;76(1):26-30.