A comparative study to test the effectiveness of triclosan coated polyglactin 910 in reduction of surgical site infection in clean wounds

Pratham Mody, Iqbal Ali, Varun Shetty, Digvijay Jadhav, Kshitij Manerikar, Vashisht Dikshit


Background: Surgical site infection (SSI) has been pointed out as the 2nd most common nosocomial infection. Since suture materials have been proven to be a contributor to SSI, they have been the focus of research and development centered on making them less conducive to bacterial overgrowth. The Triclosan coated suture slowly releases Triclosan, which is an antibacterial agent that inhibits bacterial colonization of the suture and wound site and thus, promises prevention of surgical site infection.

Methods: Total of 100 patients undergoing excision of uninfected subcutaneous benign lumps and cutaneous swellings were randomized in two groups: group A in which triclosan coated polyglactin 910 suture was used for wound closure (50 patients) and Group B in whom conventional uncoated Polyglactin 910 suture was used for wound closure (50 patients).

Results: In this study, maximum number of patients was in the age group of 46-60 years. Mean age of subjects in triclosan- coated suture group was 45.03 years while it was 47.32 in conventional uncoated suture group. Among 100 subjects in triclosan- coated suture group, 26 (52%) were males and 24 (48%) were females. In comparison to it, male and female subjects in conventional uncoated suture group were 25 (50%) each. Among 50 subjects in triclosan- coated suture group, only 2 (4.0%) had surgical site infection while in conventional uncoated suture group, 8 (16.0%) had surgical site infection. Incidence of surgical site infection with use of triclosan- coated suture was significantly lower compared to conventional uncoated suture group. (p 0.04).

Conclusions: Triclosan coated suture surely, helps in preventing surgical site infection which, not only increases the morbidity of the patient but also has long-term implications.


Polyglactin 910, SSI, Triclosan

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C.D.C. National nosocomial infections surveillance (NNIS) System Report, Data Summary from January 1990-May 1999. Am J Infect Control. 1999;27:520-32.

Klevens RM, Edwards JR, Richards CL Jr. Estimating health care-associated infectionsand deaths in U.S. hospitals. Public Health Reports. 2002;122:160-7.

National Nosocomial Infections Surveillance System. National Nosocomial Infections Surveillance (NNIS) System Report, data summary from January 1992 through June 2004, issued October 2004. Am J Infect Control. 2004;32:470-85.

Kumar A, Rai A. Prevalence of surgical site infection in general surgery in a tertiary care centre in India. Int Surg J. 2017;4(9):3101-6.

Donlan RM, Costerton JW. Biofilms: survival mechanisms of clinically relevant microorganisms. Clin Microbiol Rev. 2002;15(2):167-93.

Ming X, Rothenburger S, Nichols MM. In vivo and in vitro antibacterial efficacy of PDS plus (polidioxanone with triclosan) suture. Surg Infect. 2008;9(4):451-7.

Rothenburger S, Spangler D, Bhende S, Burkley D. In vitro antimicrobial evaluation of Coated VICRYL* Plus Antibacterial Suture (coated polyglactin 910 with triclosan) using zone of inhibition assays. Surg Infect. 2002;3(1):79-87.

Gomez-Alonso A, Garcia-Criado FJ, Parreno-Manchado FC, Garcia-Sanchez JE, Garcia-Sanchez E, Parreno-Manchado A, et al. Study of the efficacy of Coated VICRYL Plus® Antibacterial suture (coated Polyglactin 910 suture with Triclosan) in two animal models of general surgery. J Infect. 2007;54(1):82-8.

Shahane V, Bhawal S, Lele MU. Surgical site infections: A one year prospective study in a tertiary care center. Int J Health Sci. 2012;6(1):79.

Khan MA, Ansari MN, Bano S. Postoperative wound infection. Indian J Surg. 1985;48:383-6.

Berard F, Gandon J. Factors influencing the incidence of wound infection. Ann Surg. 1964;160:32-81.

Fry DE. The economic costs of surgical site infection. Surg Infect. 2002;3(1):37-43.

Hoshino S, Yoshida Y, Tanimura S, Yamauchi Y, Noritomi T, Yamashita Y. A study of the efficacy of antibacterial sutures for surgical site infection: a retrospective controlled trial. Int Surg. 2013;98(2):129.

Galal I, El-Hindawy K. Impact of using triclosan-antibacterial sutures on incidence of surgical site infection. Am J Surg. 2011;202(2):133-8.

Rozzelle CJ, Leonardo J, Li V. Antimicrobial suture wound closure for cerebrospinal fluid shunt surgery: a prospective, double-blinded, randomized controlled trial. J Neurosurg Pediatr. 2008;2(2):111-7.

Seim BE, Tønnessen T, Woldbaek PR. Triclosan-coated sutures do not reduce leg wound infections after coronary artery bypass grafting. Interactive Cardiovasc Thoracic Surg. 2012;15(3):411-5.

Mundhada AS, Tenpe S. A study of organisms causing surgical site infections and their antimicrobial susceptibility in a tertiary care government hospital. Indian J Pathol Microbiol. 2015;58(2):195.