A comparative study of single dose preoperative antibiotic prophylaxis versus five-day conventional postoperative antibiotic therapy in patient undergoing elective surgical procedure

Authors

  • Rajesh K. Basant Senior Surgeon, District Hospital, Bahraich, Uttar Pradesh, India
  • Raj Kumar Department of Surgery, Moti Lal Nehru Medical College, Allahabad, Uttar Pradesh, India
  • Vinod K. Pandey Department of Surgery, Moti Lal Nehru Medical College, Allahabad, Uttar Pradesh, India
  • Abhishek Saxena Department of Surgery, Moti Lal Nehru Medical College, Allahabad, Uttar Pradesh, India
  • Vikram Singh Department of Surgery, Moti Lal Nehru Medical College, Allahabad, Uttar Pradesh, India
  • Shivam Madeshiyaa Department of Surgery, Moti Lal Nehru Medical College, Allahabad, Uttar Pradesh, India

DOI:

https://doi.org/10.18203/2349-2902.isj20190014

Keywords:

Clean contaminated surgeries, Prophylaxis, Surgical site infection

Abstract

Background: Surgical site infections (SSIs) increase overall mortality and morbidity and increase the length of hospital stay and overall costs. With the fear of developing wound infection after surgery, author used to administer antibiotics for a period of 7-10days even in clean and clean-contaminated cases. This study aimed to fill that lacunae and there by aid the gradual shift away from over reliance on antibiotics in prevention of SSI, so author can prevent rapid development of resistance against antibiotics, prolonged hospital stays, and drug induced complication.

Methods: This facility based prospective study was carried out over a period of 1year involving 102 patients between the age group of 20-70years. All the patients in study group were given a single dose of 1gm (150mg/kg) of injection cefotaxime, 30minute before skin incision. All the cases in the control group received injection cefotaxime 1gm (150mg/kg) I.V. BD for five days.

Results: Data in the form of age, sex, type of surgery, post-operative fever, severity of pain and swelling at site of incision, duration of post-operative hospital stay, cost of treatment were noted in prescribed format and statistical analysis was done.

Conclusions: Single dose antibiotic prophylaxis is sufficient for clean and clean contaminated surgeries because there was no difference found in SSI either using single dose pre-operative antibiotic prophylaxis or using five days conventional post-operative antibiotic therapy with the added advantage of significant reduction in hospital stay and savings in resources.

References

Burdon DW. Principles of antimicrobial prophylaxis. World J Surg. 1982;6(3):262-7.

Ronald AR. Antimicrobial prophylaxis in surgery. Surgery. 1983;93(1):172-3.

Stone HH. Basic principles in the use of prophylactic antibiotics. J Antimicrob Chemother. 1984;14:33-7.

Christou NV, Nohr CW, Meakins JL. Assessing operative site infection in surgical patients. Arch Surg. 1987;122(2):165-9.

Leuva HL, Khambholja JR, Nayak KK, Shah RC. Role of antibiotics in clean surgeries: prophylaxis v/s. conventional. Guj Med J. 2014;69:96-8.

Ranjan A, Singh R, Naik PC. A comparative study of single-dose preoperative antibiotic prophylaxis versus routine long-term postoperative prophylaxis in elective general surgical cases. Inter J Med Sci Public Health. 2016;5(6):1083-7.

Jayalal JA, Kumar SJ, Thambithurai D. Effect of single-dose antibiotic prophylaxis versus conventional antibiotic therapy in surgery: a randomized controlled trial in a public teaching hospital. Inter J Sci Study. 2015;3(8):109-13.

Thejeswi PC, Shenoy D, Tauro LF, Ram SH. Comparative study of one-day perioperative antibiotic prophylaxis versus seven-day postoperative antibiotic coverage in elective surgical cases. Internet J Surg. 2012;28(2).

Patel SM, Patel MH, Patel SD, Soni ST, Kinariwala DM, Vegad MM. Surgical site infections: incidence and risk factors in a tertiary care hospital, western India. Natl J Commun Med. 2012;3(2):193-6.

Anvikar AR, Deshmukh AB, Karyakarte RP, Damle AS, Patwardhan NS, Malik AK, et al. One-year prospective study of 3280 surgical wounds. Ind J Med Microbiol. 1999;17(3):129.

Downloads

Published

2019-01-28

Issue

Section

Original Research Articles