DOI: http://dx.doi.org/10.18203/2349-2902.isj20185033

Efficacy of nano silver dressings over conventional dressings in chronic wounds

K. Suhas, P. Manvi Naga Manvi

Abstract


Background: Chronic wounds give rise to serious health problems, accompanied by a decrease in quality of life. Silver has been an effective agent with documented efficacy against wide spectrum of bacterial, viral, and fungal infections. Recently, many silver-based preparations are available for effective management of wounds. Among them silver nano particles, exhibit significantly novel and distinct physical, chemical, and biological properties. Due to their nano scale size, they have been elicited much interest in wound management. This study aims to compare the efficacy of nano silver dressing in chronic wounds with that of conventional dressings.

Methods: This was a prospective study conducted in the Department of General Surgery, Alluri Sita Rama Raju Academy of Medical Sciences from August 2017 to August 2018. A total of 100 patients with chronic wounds were included in the study and were equally divided into-Study group and Control group randomly. Swab cultures were sent in all the patients. The study group received nano silver dressings while the controls received daily dressings with normal saline soaked gauges, betadine and hydrogen peroxide. Data regarding the time required for healing, number of days required for healing and percentage of healing are noted.

Results: Nano silver dressings in the treatment of chronic wounds are found to be safe, effective, promoter of wound healing, promotes epithelization, accelerates healing, eliminates anaerobes and breaks microbial synergy more effectively than conventional dressing. Hence Nano silver spray prove to be more effective in the management of chronic wounds. In study group, 50% of patients stay for 3-4 weeks whereas in control group, 70% of patients stay for 5-6 weeks. 91-99% reduction in size of ulcer is seen in 43 out of 50 patients in study group whereas in control group only 8 out of 50 shows 91-99% reduction in size.

Conclusions: Nano silver dressings is a cost effective option in ulcer management. It decreases the period of hospitalization and reduces the burden on the health care system.


Keywords


Nano silver, Swab cultures, Wound

Full Text:

PDF

References


O’Meara SM, Cullum NA, Majid M, Sheldon TA. Systematic review of antimicrobial agents used for chronic wounds. Br J Surg. 2001;88(1):4-21.

O’Meara S, Al-Kurdi D, Ologun Y, Ovington LG. Antibiotics and antiseptics for venous leg ulcers. Cochrane Database Syst Rev. 2010;(1):CD003557.

Martin P. Wound healing-aiming for perfect skin regeneration. Science. 1997;276:75-81.

Boateng JS, Matthews KH, Stevens HNE, Eccleston GM. Wound healing dressings and drug delivery systems: a review. J Pharm Sci. 2007;97:2892-923.

Singer AJ, Clark RA. Cutaneous wound healing. New Engl J Med. 1999;341:738-46.

Purna Sai K., Babu M. Collagen based dressing-a review. Burns. 2000;26:54-62.

Foster AV, Greenhill MT, Edmonds ME. Comparing two dressings in the treatment of diabetic foot ulcers. J Wound Care. 1994;3:224-8.

Nair LS, Laurencin CT. Silver nanoparticles: Synthesis and therapeutic application. J Biomed Nanotech. 2007;3:301-16.

Muangman P, Chuntrasakul C, Silthram S, Suvanchote S, Benjathanung R, Kittidacha S, et al. Comparison of efficacy of 1% silver sulfadiazine and Acticoat for treatment of partial-thickness burn wounds. Med Assoc Thai. 2006;89(7):953-8.

Munteanu A, Florescu IP, Nitescu C. A modern method of treatment: The role of silver dressings in promoting healing and preventing pathological scarring in patients with burn wounds. J Med Life. 2016;9(3):306-15.

Kirshner R, Orsted HL, Wright JB. Matrix metalloproteinases in normal and impaired wound healing: A potential role of nanocrystalline silver. Wounds: A Compendium Clinical Research and Practice. 2002;13:4-14.

Rao H, Pai A, Hussein I, Arun A, Ram HS, Pai A, A comparative study between collagen dressings and conventional dressings in wound healing, Int J Collab Res Internal Med Publ Health. 2012;4(5):611-23.

Franks PJ, Moffat CJ. Who suffers most from leg ulceration? J Wound Care. 1998;7:383-5.

14.. Edmonds ME, Blundell MP, Morris ME, et al, Improved survival of diabetic foot. The role of specialized foot clinic. QJ med. 1986;60:763-71.

Miller C, Royal District Nursing Service. Treating bacterial burden in chronic lower leg ulcers: a randomised controlled trial comparing two antimicrobial dressings - cadexomer lodine and nanocrystalline silver: executive summary. Royal District Nursing Service, Melbourne, Melbourne, Vic, 2009.

Munter KC, Beele H, Crespi A, Gronchenig E, Basse P, Alikadic N, et al. Effect of a sustained silver-releasing dressing on ulcers with delayed healing:the CONTOP study. J Wound Care. 2006;15:199-206.