Case report of giant retroperitoneal liposarcoma in a young woman
Keywords:Liposarcoma, Retroperitoneal, Sarcoma, Surgery, Well-differentiated
Retroperitoneal liposarcoma is a rare malignant mesenchymal tumor with an annual incidence of approximately 2.5 cases per 100,000 inhabitants. It does not present specific symptoms, so its early diagnosis is difficult and in most cases it is performed when it has a large size. A 45-year-old patient with a history of increased abdominal perimeter and local discomfort was admitted in our center. After performing an abdominopelvic CT, she was diagnosed of a large, bulky tumor of lipomatous origin that significantly displaced the intestinal loops and the rest of neighboring organs. In view of the clinical suspicion of a liposarcoma, the patient underwent a resection of the lesion located in the retroperitoneum. The histopathological study determined a well differentiated retroperitoneal liposarcoma. The well-differentiated liposarcoma located in the lower limbs and the retroperitoneal space. Its age of presentation is between the fourth and sixth decade of life without finding differences between men and women. Its treatment is surgical and involves the resection of the tumor mass with non-affected surgical margins. Retroperitoneal liposarcoma is a malignant tumor whose treatment is fundamentally surgical. These tumors tend to be resistant to radiotherapy and / or chemotherapy. Among the most important prognostic factors related to survival is surgery with non-affected margins.
Caizzone A, Saladino E, Fleres F, Paviglianiti C, Iaropoli F, Mazzeo C. et al. Giant retroperitoneal liposarcoma: Case report and review of the literature. Int J Surg Case Rep. 2015;9:23-6.
Ikeguchi M, Urushibara S, Shimoda R, Saito H, Wakatsuki T. Surgical treatment of retroperitoneal liposarcoma. Yonago Acta Med. 2014 Dec;57(4):129-32.
Matthyssens LE, Creytens D, Ceelen WP. Retroperitoneal liposarcoma: current insights in diagnosis and treatment. Front Surg. 2015 Feb 10;2:4.
Taguchi S, Kume H, Fukuhara H, Morikawa T, Kakutani S, Takeshima Y et al. Symptoms at diagnosis as independent prognostic factors in retroperitoneal liposarcoma. Mol Clin Oncol. 2016 Feb;4(2):255-260.
Vijay A, Ram L. Retroperitoneal liposarcoma: a comprehensive review. Am J Clin Oncol. 2015 Apr;38(2):213-9.
Wu YX, Liu JY, Liu JJ, Yan P, Tang B, Cui YH et al. A retrospective, single-center cohort study on 65 patients with primary retroperitoneal liposarcoma. Oncol Lett. 2018 Feb;15(2):1799-810.
Zhang WD, Liu DR, Que RS, Zhou CB, Zhan CN, Zhao JG, Chen LI. Management of retroperitoneal liposarcoma: A case report and review of the literature. Oncol Lett. 2015 Jul;10(1):405-409.
Tanaka M, Kawahara T, Nishikoshi T, Hagiwara M, Imai K, Hasegawa K. Successful surgical treatment for huge retroperitoneal liposarcoma involving the pancreas, right kidney, abdominal aorta and inferior vena cava. J Surg Case Rep. 2017 Nov 23;2017(11):200.
Mansfield SA, Pollock RE, Grignol VP. Surgery for Abdominal Well-Differentiated Liposarcoma. Curr Treat Options Oncol. 2018 Jan 16;19(1):1.
Ballo MT, Zagars GK, Pollock RE, Benjamin RS, Feig BW, Cormier JN. Retroperitoneal soft tissue sarcoma: an analysis of radiation and surgical treatment. Int J Radiat Oncol Biol Phys. 2007;67:158-63.
Gronchi A, Lo Vullo S, Fiore M, Mussi C, Stacchiotti S, Collini P, et al. Aggressive surgical policies in a retrospectively reviewed single-institution case series of retroperitoneal soft tissue sarcoma patients. J Clin Oncol. 2009;27(1):24.
Bonvalot S, Rivoire M, Castaing M, Stoeckle E, le Cesne A, Blay JY, et al. Primary retroperitoneal sarcomas: a multivariate analysis of surgical factors associated with local control. J Clin Oncol. 2009;27(1):31-7.
Lewis JJ, Leung D, Woodruff JM, Brennan MF. Retroperitoneal soft-tissue sarcoma: analysis of 500 patients treated and followed at a single institution, Ann Surg. 1998;228(3):355-65.