The effect of polypropylene mesh on different layers to the formation of collagen type I/ III ratio and total collagen density in incisional hernia repair

Authors

  • Mesut Yur Department ofSurgical Oncology, Kanuni Training and Research Hospital, Trabzon, Turkey
  • Ziya Çetinkaya Department ofGeneral Surgery, Fırat University, Elazığ, Turkey
  • Tuncay Kuloğlu Department of Histology and Embryology, Fırat University, Elazığ, Turkey
  • Dürrin Özlem Dabak Department of Histology and Embryology, Fırat University, Elazığ, Turkey
  • Erhan Aygen Department of General Surgery, Fırat University, Elazığ, Turkey
  • Osman Doğru Department of General Surgery, Konya Training and Research Hospital, Konya, Turkey

DOI:

https://doi.org/10.18203/2349-2902.isj20183711

Keywords:

Collagen, Incisional hernia, Polypropylene, Wound healing

Abstract

Background: In incisional hernia patients, collagen type I/III ratio and total collagen density (TCD) emerges a main etiological factor. If they are low, recurrence risk can be high. The aim of this study was to determine the ratio of collagen type I/III and TCD after incisional hernia repair in different layers with polypropylene mesh.

Methods: In the study, 40 Wistar Albino rats were used. They were divided into four equal groups: control, preperitoneal, intraperitoneal and onlay. In control group, defect was repaired with prolene suture. In other groups, prolene mesh was placed to the different layers. Incisions were reopened 30 days later, and tissue samples were taken. Samples were stained by double-immunohistochemical methods and examined under light microscope.

Results: Collagen type I/III ratio and TCD was highest in preperitoneal group. Intraperitoneal group was the second highest group. There was no difference between onlay and control group for collagen type I/III ratio except TCD. There was a significant correlation between TCD and collagen type I/III ratio in all samples.

Conclusions: Mesh repair in different layers has an effect on TCD and collagen type I/III ratio in incisional hernia repair. Preperitoneal layer is better than other layers.

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Published

2018-08-25

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Original Research Articles