DOI: http://dx.doi.org/10.18203/2349-2902.isj20174874

Brown Jaw Tumors: challenges and outcomes

Tarek Elsayed Ftohy Abdelrahman

Abstract


Background: Brown tumors are very rare giant cell lesions that arise as a result of hyperparathyroidism, brown tumors rarely affect the mandible and maxilla and its diagnosis and treatment is very challenging and needs a high index of suspicion.

Methods: Retrospective chart review of nine cases diagnosed as brown jaw tumors treated in maxillofacial, head and neck surgery unit, department of surgery, Sohag University hospital.

Results: They were 9 patients, 3 males and 6 females with a mean age of 43.3 years. Lesions were located in the mandible (4 cases), maxilla (3 cases), both mandible and maxilla (2 cases). The main presentation was a mass lesion. Clinical examination and serum parathormone, serum calcium, serum phosphorus, neck ultrasonography, parathyroid scan was used for diagnosis. Cases did excision with parathyroidectomy. There was no recurrence during a mean follow up period of 9.3 months. All patients had satisfactory results.

Conclusions: All cases with osteolytic lesions in mandible or maxilla the possibility of brown tumors should be kept in mind especially if there is any manifestation of hyperparathyroidism. This report will aid in the recognition and treatment of the jaw brown tumors.


Keywords


Brown tumors, Hyperparathyroidism, Osteolytic lesions

Full Text:

PDF

References


Keyser JS, Postma GN. Brown Tumors of the mandible. Am J Otolaryngol. 1996;17:407-10.

Van Herden JA, Beehrs OH, Woolner LB. The pathology and surgical management of primary hyperparathyroidism. Surg Cli North ASm. 1997;57:557.

Vaishya R, Agarwal AK, Singh H, Vijay V. Multiple ‘Brown Tumours’ Masquerading as Metastatic Bone Disease. Cureus. 2015 Dec;7(12):e431.

Mirra JM. Giant cell tumors. Bone Tumors Clinical, Radiologic, and Pathologic Correlations. 1989:941-1020.

Taakeshita T, Tanaka H, Harasawa A. Brown Tumors of the sphenoid sinus in a patient with secondary Hyperparathyroidism: CT and MRI imaging finding. Radiata Med. 2004;22(4):265-8.

Hsieh MC, Ko JY, Eng HL. Pathologic fracture of the distal femur in osteitis fibrosa cystica simulating metastatic disease. Arch Orthop Trauma Surg. 2004;124(7):498-501.

Meng Z, Zhu M, He Q, Tian W, Zhang Y, Tan J. Clinical implication of brown tumors uptake in whole-body 99mtc-sestamibi scans for primary hyperparathyroidism. Nucl Med Commun. 2011;32:708-15.

Dusunsel R, Guney E, Gunduz Z. Maxillary brown tumors caused by secondary hyperparathyroidism in a boy. Pediatr Nephrol. 2000;14:529-31.

Mania AM, Kraus H. successful treatment of osteitis fibrosa cystica from primary hyperparathyroidism. Case Rep Orthop. 2012;2012:145760.

Scott SN, Graham SM, Sato Y, Robinson RA. Brown tumor of palate in a patient with primary hyperparathyroidism. Ann Otol Rhinol Laryngol 1999;108:91-4.

Yamazaki H, Ota Y, Aoki T, Karakida K. Brown Tumor of the mandible and maxilla: progressive mandibular brown tumor after removal of parathyroid adenoma. J Oral Maxillofac Surg. 2003;6:719-22.