DOI: http://dx.doi.org/10.18203/2349-2902.isj20174910

Pleomorphic xanthoastrocytoma

Sunil V. Jagtap, Sonal O. Gupta, Cyrus Dara Jokhi, Swati S. Jagtap

Abstract


Pleomorphic Xanthoastrocytomas (PXAs) are rare neoplasm of all astrocytic glial tumors, which occurs commonly in children and young adulthood. We present a case of 75-year male who presented with right side involuntary movements, unconsciousness and tongue bite. On radiological examination CT Scan Head (plain) showed well circumscribed isodense lesion measuring 7.2 x 5.6 x 4.8 cm at the temporoparietal region left side causing displacement of basal ganglia. On histopathological examination, diagnosed as pleomorphic xanthoastrocytoma, of left temporoparietal region. We present this report for its presentation at late age, its clinical, radiological and histomorphological features.


Keywords


Astrocytoma, Histopathology, Supratentorial tumors

Full Text:

PDF

References


Kepes JJ, Rubinstein LJ, Eng LF. Pleomorphic xanthoastrocytoma: a distinctive meningocerebral glioma of young subjects with relatively favourable prognosis a study of 12 cases. Cancer. 1979;44(5):1839-52.

Gallo P, Cecchi PC, Locatelli F, Rizzo P, Ghimenton C, Gerosa M, Pinna G. Pleomorphic xanthoastrocytoma: long-term results of surgical treatment and analysis of prognostic factors. B J Neurosurg. 2013;27(6):759-64.

Hirose T, Ishizawa K, Sugiyama K, Kageji T, Ueki K, Kannuki S. Pleomorphic xanthoastrocytoma: a comparative pathological study between conventional and anaplastic types. Histopathol. 2008;52(2):183-93.

Louis DN, Ohgaki H, Wiestler OD, Cavenee WK, Burger PC, Jouvet A, et al. The 2007 WHO classification of tumours of the central nervous system. Acta Neuropathologica. 2007;114(2):97-109.

Fouladi M, Jenkins J, Burger P, Langston J, Merchant T, Heideman R, et al. Pleomorphic xanthoastrocytoma: favorable outcome after complete surgical resection. Neuro-Oncol. 2001;3(3):184-92.

Perkins SM, Mitra N, Fei W, Shinohara ET. Patterns of care and outcomes of patients with pleomorphic xanthoastrocytoma: a SEER analysis. J Neuro-Oncol. 2012;110(1):99-104.

Giannini C, Scheithauer BW, Burger PC, Brat DJ, Wollan PC, Lach B, et al. Pleomorphic xanthoastrocytoma. Cancer. 1999;85(9):2033-45.

Bayindir C, Balak N, Karasu A, Kasaro─člu D. Anaplastic pleomorphic xanthoastrocytoma. Child's nervous system. 1997;13(1):50-6.

MacCaulay RJ, Becker LE, Jay V. Transformation of pleomorphic xanthoastrocytoma to glioblastoma: a case documented with immunogold electron microscopy. J Neuropathol Exper Neurol. 1992; 51:365.

Tella OI, Herculano MA, Prandini MN, Stavale JN, Aguiar PH. Malignant transformation of pleomorphic xanthoastrocytoma: case report. Arch Neuro-Psychiatry. 2003;61(1):104-6.

Schmidt Y, Kleinschmidt-DeMasters BK, Aisner DL, Lillehei KO, Damek D. Anaplastic PXA in adults: case series with clinicopathologic and molecular features. J Neuro Oncol. 2013;111(1):59-69.

Lubansu A, Rorive S, David P, Sariban E, Seligmann R, Brotchi J, et al. Cerebral anaplastic pleomorphic xanthoastrocytoma with meningeal dissemination at first presentation. Child's nervous system. 2004;20(2):119-22.

Schindler G, Capper D, Meyer J, Janzarik W, Omran H, Herold-Mende C, et al. Analysis of BRAF V600E mutation in 1,320 nervous system tumors reveals high mutation frequencies in pleomorphic xanthoastrocytoma, ganglioglioma and extra-cerebellar pilocytic astrocytoma. Acta Neuropathol. 2011;121(3):397-405.