Posterior fossa metastasis of retinoblastoma accompanying a supratentorial second focus in a child: a case report

Fatih Yakar, Ihsan Dogan, Elif Ozyurek, Onur Ozgural, Umit Eroglu, Melih Bozkurt


The central nervous system, as a metastatic focus, has an extreme predisposition to retinoblastoma and has been indicated as the most common site for this disease. Herein, we report a 4-year-old girl presenting with multiple cranial metastases of retinoblastoma. To our knowledge, this presented case is valuable and significant in terms of being reported as the first cerebellar metastasis of retinoblastoma in the literature and removing this lesion together with supratentorial focus in a single operation with a single skin incision. 


Metastasis, Posterior fossa, Retinoblastoma

Full Text:



Potts DG, Abbott GF, von Sneidern JV. National cancer institute study: evaluation of computed tomography in the diagnosis of intracranial neoplasms III. Metastatic tumors. Radiol. 1980;136:657-64.

Wiens AL, Hattab EM. The pathological spectrum of solid CNS metastases in the pediatric population. J Neurosurg Pediatr. 2014;14(2):129-35.

Leal-Leal CA, Rivera-Luna R, Flores-Rojo M, Juárez-Echenique JC, Ordaz JC, Amador-Zarco J. Survival in extra-orbital metastatic retinoblastoma: treatment results. Clin Transl Oncol. 2006;8(1):39-44.

Grossman RI, Yousem DM. Neuroradiology: The Requisites. 3rd edition. Mosby; 2010:90.

Nordena AD, Wend PY, Kesarid S. Brain metastases. Curr Opin Neurol. 2005;18:654-61.

Kivela T. The epidemiological challenge of the most frequent eye cancer: retinoblastoma, an issue of birth and death. Br J Ophthalmol. 2009;93(9):1129-31.

Knudson Jr AG. Mutation and cancer: statistical study of retinoblastoma. Proc Natl Acad Sci USA. 1971;68(4):820-3.

Kingston J. Understanding retinoblastoma. London: The Retinoblastoma Society; 2002:23.

Herrlinger U, Steinbrecher A, Rieger J, Hau P, Kortmann RD, Meyermann R, et al. Adult medulloblastoma: prognostic factors and response to therapy at diagnosis and at relapse. J Neurol. 2005;252:291-9.

Kıratlı H, Tarlan B. Current approaches in the treatment of retinoblastoma. Turk J Ophthalmol. 2014;44:22-8.

MacKay CJ, Abramson DH, Ellsworth RM. Metastatic patterns of retinoblastoma. Arch Ophthalmol. 1984;102(3):391-6.

Bouffet E, Doumi N, Thiesse P, Mottolese C, Jouvet A, Lacroze M, et al. Brain metastases in children with solid tumors. Cancer. 2005;79(2):403-10.

Atlas SW, Kemp SS, Rorke L, Grossman RI. Hemorrhagic intracranial retinoblastoma metastases: MR-pathology correlation. J Comput Assist Tomogr. 1988;12(2):286-9.

De Martino ML, Amantea SL, Ulbrich JM, Barbosa-Coutinho LM. Retinoblastoma with suprasellar extension: report of a case. Arq Neuropsiquiatr. 1986;44(2):191-4.

Katayama Y, Tsubokawa T, Yamamoto T, Nemoto N. Ectopic retinoblastoma within the 3rd ventricle: case report: Neurosurg. 1991;28(1):158-61.