Prevalence of Helicobacter pylori infection among dyspepsia patients with mucosal lesion in tertiary care hospital

Authors

  • Amit S. Yadav Department of Gastroenterology, United CIIGMA Hospital, Aurangabad, Maharashtra, India
  • Umesh B. Kulkarni Department of Gastroenterology, United CIIGMA Hospital, Aurangabad, Maharashtra, India
  • Bharat C. Kumar Department of Gastroenterology, United CIIGMA Hospital, Aurangabad, Maharashtra, India
  • Unmesh V. Takalkar Department of Gastroenterology, United CIIGMA Hospital, Aurangabad, Maharashtra, India

DOI:

https://doi.org/10.18203/2349-2902.isj20182234

Keywords:

Dyspepsia, H. pylori, Rapid urease test

Abstract

Background: Helicobacter pylori (H. pylori), a curved rod shaped bacteria, is found to be associated with acid peptic disease patients, more in ulcer than non-ulcer, leading to a belief that H. pylori plays a role in its etiopathogenesis. In this study we examine the prevalence of H. pylori infection among dyspepsia patients with mucosal lesion.

Methods: 300 patients of dyspepsia were enrolled in the study as per inclusion/exclusion criteria for a period of eight months. Enrolled patients were subjected to upper gastro-intestinal endoscopy and findings were recorded. Biopsy specimen taken from mucosal lesions were immediately inoculated on ‘RUT dry kit’ to test for H. pylori infection.

Results: 234 out of 300 patients (78%) were found to be positive for H. pylori infection. The incidence of H. pylori infection was higher in patients with ulcer dyspepsia (88.46%) when compared to the patients with non-ulcer dyspepsia (72.44%).

Conclusions: Prevalence of H. pylori infection was high and was found to have an association with ulcer dyspepsia allowing us to conclude that H. pylori may have a role in its etiopathogenesis.

References

Al-Humayed SM, Mohammed-Elbagir AK, Al- Wabel AA, Argobi YA. The changing pattern of upper gastrointestinal lesions in Southern Saudi Arabia: an endoscopic study. Saudi J Gastroenterol. 2010;16(1):35-7.

Ramin N, Mehrdad S, Mohammad RF, Amirreza D, Laleh M. Prevalence of Helicobacter pylori in patients with dyspepsia. Jundishapur J Microbiol. 2014;7(9):12676.

Aziz AFA, Hamzah Z, Tong SF, Nadeson S, Wan Puteh SE. Helicobacter pylori related dyspepsia: prevalence and treatment outcomes at University Kebangsaan Malaysia-Primary Care Centre. Asia Pacific Fam Med. 2009;8:4.

Abboud AA, Moussawi HA, Rustom M, Khalek WA. Epidemiology of Helicobacter pylori infection among symptomatic patients, correlation with endoscopic findings and it’s association with type II diabetes mellitus. J Gastroint Dig Syst. 2017;7(3):1-5.

Michel A, Waterboer T, Kist M, Pawlita M. Helicobacter pylori multiplex serology. Helicobacter. 2009;14(6):525-35.

Thijs JC, Van Zonet AA, Thijs WJ. Diagnostic test for H. pylori: a prospective evaluation of their accuracy without selecting a single test as the gold standard. Am J Gastroenterol. 1996;91:2125-9.

Rosenstock S, Kay L, Rosenstock C. Relationship between Helicobacter pylori infection and gastrointestinal symptoms and syndromes. Gut. 1997;41(2):169-76.

Oluwasola AO, Ola SO, Saliu L, Solanke TF. Helicobacter pylori infection in South Nigerians: a serological study of dyspeptic patients and healthy individuals. West Afr J Med. 2002;21(2):138-41.

Marshall BJ, Warren JR. Unidentified curved bacilli in the stomach of patients with Gastritis and peptic ulceration. Lancet. 1984;1311-15.

Wulfen Von, Heeseman J, Butzow GH, Loning T, Laufs R. Detection of C. Pyloridis in patients with antral gastritis and peptic ulcers by culture, compliment fixation test and immunoblot. J Clin Microbiol. 1986;24:716-19.

Vaira D, Miglioli M, Mulè P, Holton J, Menegatti M, Vergura M, et al. Prevalence of peptic ulcer in Helicobacter pylori positive blood donors. Gut.1994;35:309-12.

Sobala GM, Crabtree JE, Pentith JA, Rathbone BJ, Shallcross TM, Wyatt JI et al. Screening dyspepsia by serology to Helicobacter pylori. Lancet. 1991;338:94-6.

Patel P, Mendall MA, Khulusi S, Molineaux N, Levy J, Maxwell JD et al. Salivary antibodies to Helicobacter pylori: screening dyspeptic patients before endoscopy. Lancet. 1994;344:511-12.

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Published

2018-05-24

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Original Research Articles